Matches in SemOpenAlex for { <https://semopenalex.org/work/W1640545866> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1640545866 endingPage "5840" @default.
- W1640545866 startingPage "5834" @default.
- W1640545866 abstract "Abstract SJL mice provide an interesting paradigm to examine the role(s) of APC in the differential induction of Th1 and Th2 cells. Immunization of young male SJL mice results in the preferential induction of Th2 cells, whereas Th1 cells are induced in age-matched female or older male SJL mice. The absence of Th1 responses in young male mice is associated with in vivo IL-4 and IL-10 down-regulating Mac-3+ APC priming of Th1 cells. The present report examines the mechanism of this APC-dependent induction of Th subsets. Examination of the surface expression of MHC class II, adhesion molecules (CD11a, CD11b, CD48, CD54, and CD102) or costimulatory molecules (CD24, CD80, and CD86) showed no differences between male- and female-derived Mac-3+ APC populations. In addition, no differences were detected in IL-1alpha, IL-1beta, IL-18, TNF-alpha, or IL-12 p35 mRNA expression. However, reduced expression of both IL-10 and IL-12 p40 mRNA were found in Mac-3+ cells from male mice compared with those in Mac-3+ cells from female mice. Anti-IL-4 or anti-IL-10 mAb treatment of young male donor mice eliminated the reduction of both IL-10 and IL-12 p40 mRNA, suggesting that the Th2 inducer phenotype is related to a decreased IL-12 secretion. Consistent with this idea, fewer IL-12 p40-secreting Mac-3+ cells were found in male mice compared with female mice, and treatment with rIL-12 resulted in the priming of Th1 cells in male mice. These data suggest that increased Th2 cytokines in vivo before encounter with Ag inhibit APC expression of IL-12, resulting in the preferential induction of Th2 cells in male SJL mice." @default.
- W1640545866 created "2016-06-24" @default.
- W1640545866 creator A5039838353 @default.
- W1640545866 creator A5061444710 @default.
- W1640545866 date "1997-12-15" @default.
- W1640545866 modified "2023-10-18" @default.
- W1640545866 title "In vivo effects of T helper cell type 2 cytokines on macrophage antigen-presenting cell induction of T helper subsets." @default.
- W1640545866 doi "https://doi.org/10.4049/jimmunol.159.12.5834" @default.
- W1640545866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9550379" @default.
- W1640545866 hasPublicationYear "1997" @default.
- W1640545866 type Work @default.
- W1640545866 sameAs 1640545866 @default.
- W1640545866 citedByCount "40" @default.
- W1640545866 countsByYear W16405458662012 @default.
- W1640545866 countsByYear W16405458662013 @default.
- W1640545866 countsByYear W16405458662014 @default.
- W1640545866 countsByYear W16405458662015 @default.
- W1640545866 countsByYear W16405458662016 @default.
- W1640545866 countsByYear W16405458662019 @default.
- W1640545866 crossrefType "journal-article" @default.
- W1640545866 hasAuthorship W1640545866A5039838353 @default.
- W1640545866 hasAuthorship W1640545866A5061444710 @default.
- W1640545866 hasBestOaLocation W16405458661 @default.
- W1640545866 hasConcept C100701293 @default.
- W1640545866 hasConcept C147483822 @default.
- W1640545866 hasConcept C150903083 @default.
- W1640545866 hasConcept C153911025 @default.
- W1640545866 hasConcept C154317977 @default.
- W1640545866 hasConcept C191732599 @default.
- W1640545866 hasConcept C202751555 @default.
- W1640545866 hasConcept C203014093 @default.
- W1640545866 hasConcept C207001950 @default.
- W1640545866 hasConcept C207936829 @default.
- W1640545866 hasConcept C2776090121 @default.
- W1640545866 hasConcept C2778297628 @default.
- W1640545866 hasConcept C2778814158 @default.
- W1640545866 hasConcept C2781101188 @default.
- W1640545866 hasConcept C39347974 @default.
- W1640545866 hasConcept C55493867 @default.
- W1640545866 hasConcept C59822182 @default.
- W1640545866 hasConcept C67662055 @default.
- W1640545866 hasConcept C81444415 @default.
- W1640545866 hasConcept C86803240 @default.
- W1640545866 hasConcept C8891405 @default.
- W1640545866 hasConceptScore W1640545866C100701293 @default.
- W1640545866 hasConceptScore W1640545866C147483822 @default.
- W1640545866 hasConceptScore W1640545866C150903083 @default.
- W1640545866 hasConceptScore W1640545866C153911025 @default.
- W1640545866 hasConceptScore W1640545866C154317977 @default.
- W1640545866 hasConceptScore W1640545866C191732599 @default.
- W1640545866 hasConceptScore W1640545866C202751555 @default.
- W1640545866 hasConceptScore W1640545866C203014093 @default.
- W1640545866 hasConceptScore W1640545866C207001950 @default.
- W1640545866 hasConceptScore W1640545866C207936829 @default.
- W1640545866 hasConceptScore W1640545866C2776090121 @default.
- W1640545866 hasConceptScore W1640545866C2778297628 @default.
- W1640545866 hasConceptScore W1640545866C2778814158 @default.
- W1640545866 hasConceptScore W1640545866C2781101188 @default.
- W1640545866 hasConceptScore W1640545866C39347974 @default.
- W1640545866 hasConceptScore W1640545866C55493867 @default.
- W1640545866 hasConceptScore W1640545866C59822182 @default.
- W1640545866 hasConceptScore W1640545866C67662055 @default.
- W1640545866 hasConceptScore W1640545866C81444415 @default.
- W1640545866 hasConceptScore W1640545866C86803240 @default.
- W1640545866 hasConceptScore W1640545866C8891405 @default.
- W1640545866 hasIssue "12" @default.
- W1640545866 hasLocation W16405458661 @default.
- W1640545866 hasLocation W16405458662 @default.
- W1640545866 hasOpenAccess W1640545866 @default.
- W1640545866 hasPrimaryLocation W16405458661 @default.
- W1640545866 hasRelatedWork W1600922886 @default.
- W1640545866 hasRelatedWork W1640545866 @default.
- W1640545866 hasRelatedWork W188365280 @default.
- W1640545866 hasRelatedWork W2009025366 @default.
- W1640545866 hasRelatedWork W2028926231 @default.
- W1640545866 hasRelatedWork W2041302454 @default.
- W1640545866 hasRelatedWork W2278369333 @default.
- W1640545866 hasRelatedWork W2417011131 @default.
- W1640545866 hasRelatedWork W4251394305 @default.
- W1640545866 hasRelatedWork W4313344705 @default.
- W1640545866 hasVolume "159" @default.
- W1640545866 isParatext "false" @default.
- W1640545866 isRetracted "false" @default.
- W1640545866 magId "1640545866" @default.
- W1640545866 workType "article" @default.