Matches in SemOpenAlex for { <https://semopenalex.org/work/W1640686132> ?p ?o ?g. }
- W1640686132 endingPage "314" @default.
- W1640686132 startingPage "303" @default.
- W1640686132 abstract "Hairpin ribozymes possess the properties of RNA sequence‐specific recognition and site‐specific cleavage. These properties make them a powerful extension of the antisense approach for the inhibition of gene expression. From a randomized RNA pool of hairpin ribozymes, using the systematic evolution of ligands by exponential enrichment, we have obtained an adenine‐dependent hairpin ribozyme, Tpl2/Cot (tumour progression locus 2) ribozyme, which cleaves the Tpl2/Cot kinase mRNA sequence at nucleotides A225 ↓ G226 relative to the start codon of translation. This serine/threonine kinase activates the mitogen‐activated protein kinase pathway implicated in cell proliferation in cancer. The selected ‘ Tpl2/Cot ‐YL ribozyme’ efficiently cleaves its target sequence in cis and in trans ; furthermore, the ribozyme efficiently cleaves a longer target sequence of 54 nucleotides in trans , as well as the full‐length mRNA." @default.
- W1640686132 created "2016-06-24" @default.
- W1640686132 creator A5033146410 @default.
- W1640686132 creator A5047989462 @default.
- W1640686132 creator A5074067561 @default.
- W1640686132 creator A5074327992 @default.
- W1640686132 date "2008-12-12" @default.
- W1640686132 modified "2023-10-18" @default.
- W1640686132 title "In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene" @default.
- W1640686132 cites W1509315828 @default.
- W1640686132 cites W1586373415 @default.
- W1640686132 cites W1642023497 @default.
- W1640686132 cites W1969387023 @default.
- W1640686132 cites W1974704457 @default.
- W1640686132 cites W1985111266 @default.
- W1640686132 cites W1987643271 @default.
- W1640686132 cites W1992778012 @default.
- W1640686132 cites W1995309943 @default.
- W1640686132 cites W1996962471 @default.
- W1640686132 cites W2003698664 @default.
- W1640686132 cites W2010670485 @default.
- W1640686132 cites W2012555497 @default.
- W1640686132 cites W2014508207 @default.
- W1640686132 cites W2023363067 @default.
- W1640686132 cites W2029998151 @default.
- W1640686132 cites W2032261877 @default.
- W1640686132 cites W2034658941 @default.
- W1640686132 cites W2036795228 @default.
- W1640686132 cites W2043951259 @default.
- W1640686132 cites W2050956602 @default.
- W1640686132 cites W2054731026 @default.
- W1640686132 cites W2058274697 @default.
- W1640686132 cites W2059884965 @default.
- W1640686132 cites W2069348762 @default.
- W1640686132 cites W2079321730 @default.
- W1640686132 cites W2088892367 @default.
- W1640686132 cites W2092525178 @default.
- W1640686132 cites W2098393725 @default.
- W1640686132 cites W2112401119 @default.
- W1640686132 cites W2113709051 @default.
- W1640686132 cites W2121287580 @default.
- W1640686132 cites W2146184097 @default.
- W1640686132 cites W2151863773 @default.
- W1640686132 cites W2158626412 @default.
- W1640686132 cites W2159872424 @default.
- W1640686132 cites W2324000374 @default.
- W1640686132 cites W52968187 @default.
- W1640686132 doi "https://doi.org/10.1111/j.1742-4658.2008.06780.x" @default.
- W1640686132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19054068" @default.
- W1640686132 hasPublicationYear "2008" @default.
- W1640686132 type Work @default.
- W1640686132 sameAs 1640686132 @default.
- W1640686132 citedByCount "8" @default.
- W1640686132 countsByYear W16406861322013 @default.
- W1640686132 countsByYear W16406861322016 @default.
- W1640686132 countsByYear W16406861322021 @default.
- W1640686132 crossrefType "journal-article" @default.
- W1640686132 hasAuthorship W1640686132A5033146410 @default.
- W1640686132 hasAuthorship W1640686132A5047989462 @default.
- W1640686132 hasAuthorship W1640686132A5074067561 @default.
- W1640686132 hasAuthorship W1640686132A5074327992 @default.
- W1640686132 hasBestOaLocation W16406861321 @default.
- W1640686132 hasConcept C104317684 @default.
- W1640686132 hasConcept C105580179 @default.
- W1640686132 hasConcept C107745601 @default.
- W1640686132 hasConcept C1342335 @default.
- W1640686132 hasConcept C149364088 @default.
- W1640686132 hasConcept C153911025 @default.
- W1640686132 hasConcept C169663058 @default.
- W1640686132 hasConcept C184235292 @default.
- W1640686132 hasConcept C185592680 @default.
- W1640686132 hasConcept C30951146 @default.
- W1640686132 hasConcept C4718897 @default.
- W1640686132 hasConcept C55493867 @default.
- W1640686132 hasConcept C66144319 @default.
- W1640686132 hasConcept C67705224 @default.
- W1640686132 hasConcept C76346623 @default.
- W1640686132 hasConcept C86803240 @default.
- W1640686132 hasConcept C95444343 @default.
- W1640686132 hasConcept C97029542 @default.
- W1640686132 hasConceptScore W1640686132C104317684 @default.
- W1640686132 hasConceptScore W1640686132C105580179 @default.
- W1640686132 hasConceptScore W1640686132C107745601 @default.
- W1640686132 hasConceptScore W1640686132C1342335 @default.
- W1640686132 hasConceptScore W1640686132C149364088 @default.
- W1640686132 hasConceptScore W1640686132C153911025 @default.
- W1640686132 hasConceptScore W1640686132C169663058 @default.
- W1640686132 hasConceptScore W1640686132C184235292 @default.
- W1640686132 hasConceptScore W1640686132C185592680 @default.
- W1640686132 hasConceptScore W1640686132C30951146 @default.
- W1640686132 hasConceptScore W1640686132C4718897 @default.
- W1640686132 hasConceptScore W1640686132C55493867 @default.
- W1640686132 hasConceptScore W1640686132C66144319 @default.
- W1640686132 hasConceptScore W1640686132C67705224 @default.
- W1640686132 hasConceptScore W1640686132C76346623 @default.
- W1640686132 hasConceptScore W1640686132C86803240 @default.
- W1640686132 hasConceptScore W1640686132C95444343 @default.
- W1640686132 hasConceptScore W1640686132C97029542 @default.