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- W1640703157 endingPage "288" @default.
- W1640703157 startingPage "263" @default.
- W1640703157 abstract "Polyethylenimines (PEIs) have proven to be highly efficient and versatile agents for nucleic acid delivery in vitro and in vivo. Despite the low biodegradability of these polymers, they have been used in several clinical trials and the results suggest that the nucleic acid/PEI complexes have a good safety profile. The high transfection efficiency of PEIs probably relies on the fact that these polymers possess a stock of amines that can undergo protonation during the acidification of endosomes. This buffering capacity likely enhances endosomal escape of the polyplexes through the “proton sponge” effect. PEIs have also attracted great interest because the presence of many amino groups allow for easy chemical modifications or conjugation of targeting moieties and hydrophilic polymers. In the present chapter, we summarize and discuss the mechanism of PEI-mediated transfection, as well as the recent developments in PEI-mediated DNA, antisense oligonucleotide, and siRNA delivery." @default.
- W1640703157 created "2016-06-24" @default.
- W1640703157 creator A5011013157 @default.
- W1640703157 creator A5041253106 @default.
- W1640703157 date "2014-01-01" @default.
- W1640703157 modified "2023-10-13" @default.
- W1640703157 title "Recent Developments in Nucleic Acid Delivery with Polyethylenimines" @default.
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