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- W1640783759 abstract "Objective: To compare the efficacy of oral ibuprofen with that of intravenous indomethacin for closure of significant patent ductus arteriosus (PDA) in premature infants. Study design: We conducted a prospective randomized controlled trial on premature infants (gestational age 0.2). Bowel perforation occurred in 4 infants in the indomethacin group and 1 infant in the ibuprofen group, while benign feeding intolerance developed in 3 and 4 infants respectively. No infants developed thrombocytopenia and there were no significant renal function changes in either group. However, there were five mortalities in the indomethacin group and three in the ibuprofen group. Conclusion: This study suggests that oral ibuprofen could be a valid alternative to indomethacin for the treatment of PDA in premature infants < 34 weeks. Although ibuprofen was associated with less side effects, larger cohort studies are needed to address safety of the use of oral ibuprofen in premature infants before any recommendation." @default.
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- W1640783759 date "2008-01-01" @default.
- W1640783759 modified "2023-09-22" @default.
- W1640783759 title "A randomized controlled trial on the use of oral ibuprofen to close patent ductus arteriosus in premature infants" @default.
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