Matches in SemOpenAlex for { <https://semopenalex.org/work/W1640815631> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1640815631 endingPage "1513" @default.
- W1640815631 startingPage "1506" @default.
- W1640815631 abstract "The motility of the small intestine in unanesthetized rats receiving berberine sulfate (0.2, 2.0, and 20.0 mg/kg i.p.) was investigated. Motility was determined by two methods: myoelectric activity was monitored with indwelling bipolar electrodes, and intestinal transit was measured by the movement of radiochromium (Na51CrO4). The 20.0-mg/kg dose caused a marked inhibition of spike activity for 21.8 +/- 7.0 min and disrupted activity fronts of the migrating myoelectric complex for 212.3 min. Berberine, 2.0 mg/kg i.p., disrupted migrating myoelectric complexes for 64.6 min but spike inhibition was not observed. Transit of the small intestine was significantly (p less than 0.001) delayed at 15 and 100 min after the highest dose of berberine. Naloxone blocked the spike inhibition noted with 20.0 mg/kg of berberine but failed to improve transit. Phentolamine blocked spike inhibition and was associated with a significantly earlier return of activity fronts of the migrating myoelectric complex. Animals pretreated with this antagonist tended toward a higher geometric center in transit studies than those injected with berberine alone. Berberine was also administered by various routes (intraperitoneal injection, intravenous injection, orogastric gavage, and intraluminal injection). An intraperitoneal injection was 10-fold more potent than an intravenous injection. Orogastric gavage and intraluminal administration of berberine did not alter intestinal motility. In summary, berberine sulfate significantly inhibits myoelectric activity and transit of the small intestine. This appears to be partially mediated by opioid and alpha-adrenergic receptors. The antidiarrheal properties of berberine may be mediated, at least in part, by its ability to delay small intestinal transit." @default.
- W1640815631 created "2016-06-24" @default.
- W1640815631 creator A5061317637 @default.
- W1640815631 creator A5075836622 @default.
- W1640815631 date "1989-06-01" @default.
- W1640815631 modified "2023-09-25" @default.
- W1640815631 title "Effect of berberine on myoelectric activity and transit of the small intestine in rats" @default.
- W1640815631 cites W1504795337 @default.
- W1640815631 cites W1967167260 @default.
- W1640815631 cites W1977370690 @default.
- W1640815631 cites W1980137900 @default.
- W1640815631 cites W1983089451 @default.
- W1640815631 cites W1986852617 @default.
- W1640815631 cites W2013171242 @default.
- W1640815631 cites W2103542073 @default.
- W1640815631 cites W2109299850 @default.
- W1640815631 cites W2134815796 @default.
- W1640815631 cites W2145147747 @default.
- W1640815631 cites W2149180873 @default.
- W1640815631 cites W2338277320 @default.
- W1640815631 doi "https://doi.org/10.1016/0016-5085(89)90519-2" @default.
- W1640815631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2714578" @default.
- W1640815631 hasPublicationYear "1989" @default.
- W1640815631 type Work @default.
- W1640815631 sameAs 1640815631 @default.
- W1640815631 citedByCount "22" @default.
- W1640815631 countsByYear W16408156312012 @default.
- W1640815631 countsByYear W16408156312013 @default.
- W1640815631 countsByYear W16408156312016 @default.
- W1640815631 countsByYear W16408156312017 @default.
- W1640815631 countsByYear W16408156312019 @default.
- W1640815631 countsByYear W16408156312020 @default.
- W1640815631 countsByYear W16408156312021 @default.
- W1640815631 countsByYear W16408156312022 @default.
- W1640815631 crossrefType "journal-article" @default.
- W1640815631 hasAuthorship W1640815631A5061317637 @default.
- W1640815631 hasAuthorship W1640815631A5075836622 @default.
- W1640815631 hasBestOaLocation W16408156311 @default.
- W1640815631 hasConcept C126322002 @default.
- W1640815631 hasConcept C134018914 @default.
- W1640815631 hasConcept C170493617 @default.
- W1640815631 hasConcept C185592680 @default.
- W1640815631 hasConcept C2776885963 @default.
- W1640815631 hasConcept C2777667214 @default.
- W1640815631 hasConcept C2777882243 @default.
- W1640815631 hasConcept C2778750930 @default.
- W1640815631 hasConcept C2780116568 @default.
- W1640815631 hasConcept C2780159080 @default.
- W1640815631 hasConcept C35147842 @default.
- W1640815631 hasConcept C54355233 @default.
- W1640815631 hasConcept C55493867 @default.
- W1640815631 hasConcept C58207958 @default.
- W1640815631 hasConcept C71240020 @default.
- W1640815631 hasConcept C71924100 @default.
- W1640815631 hasConcept C86803240 @default.
- W1640815631 hasConcept C98274493 @default.
- W1640815631 hasConceptScore W1640815631C126322002 @default.
- W1640815631 hasConceptScore W1640815631C134018914 @default.
- W1640815631 hasConceptScore W1640815631C170493617 @default.
- W1640815631 hasConceptScore W1640815631C185592680 @default.
- W1640815631 hasConceptScore W1640815631C2776885963 @default.
- W1640815631 hasConceptScore W1640815631C2777667214 @default.
- W1640815631 hasConceptScore W1640815631C2777882243 @default.
- W1640815631 hasConceptScore W1640815631C2778750930 @default.
- W1640815631 hasConceptScore W1640815631C2780116568 @default.
- W1640815631 hasConceptScore W1640815631C2780159080 @default.
- W1640815631 hasConceptScore W1640815631C35147842 @default.
- W1640815631 hasConceptScore W1640815631C54355233 @default.
- W1640815631 hasConceptScore W1640815631C55493867 @default.
- W1640815631 hasConceptScore W1640815631C58207958 @default.
- W1640815631 hasConceptScore W1640815631C71240020 @default.
- W1640815631 hasConceptScore W1640815631C71924100 @default.
- W1640815631 hasConceptScore W1640815631C86803240 @default.
- W1640815631 hasConceptScore W1640815631C98274493 @default.
- W1640815631 hasIssue "6" @default.
- W1640815631 hasLocation W16408156311 @default.
- W1640815631 hasLocation W16408156312 @default.
- W1640815631 hasOpenAccess W1640815631 @default.
- W1640815631 hasPrimaryLocation W16408156311 @default.
- W1640815631 hasRelatedWork W1971852532 @default.
- W1640815631 hasRelatedWork W2033472167 @default.
- W1640815631 hasRelatedWork W2034583712 @default.
- W1640815631 hasRelatedWork W2057262151 @default.
- W1640815631 hasRelatedWork W2063619316 @default.
- W1640815631 hasRelatedWork W2087338101 @default.
- W1640815631 hasRelatedWork W2094143912 @default.
- W1640815631 hasRelatedWork W2162607362 @default.
- W1640815631 hasRelatedWork W2169225653 @default.
- W1640815631 hasRelatedWork W2414846389 @default.
- W1640815631 hasVolume "96" @default.
- W1640815631 isParatext "false" @default.
- W1640815631 isRetracted "false" @default.
- W1640815631 magId "1640815631" @default.
- W1640815631 workType "article" @default.