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• W1641119017 abstract "Soluble CD30 (sCD30), a transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily, has been shown to be associated with various pathological conditions. This study was designed to measure the levels of serum sCD30 in patients with ankylosing spondylitis (AS) and to evaluate the relationships between serum sCD30 levels and other disease severity-related indexes, including bath ankylosing spondylitis disease activity index (BASDAI), ankylosing spondylitis disease activity score (ASDAS), and bath ankylosing spondylitis functional index (BASFI). Our results demonstrated significantly elevated sCD30 levels in AS patients compared to healthy controls (HCs) with mean values of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>32.0</mml:mn><mml:mo>±</mml:mo><mml:mn>12.2</mml:mn></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>24.9</mml:mn><mml:mo>±</mml:mo><mml:mn>8.0</mml:mn></mml:math> ng/mL, respectively<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mo stretchy=false>(</mml:mo><mml:msup><mml:mrow><mml:mi>P</mml:mi></mml:mrow><mml:mrow><mml:mi>*</mml:mi><mml:mi>*</mml:mi></mml:mrow></mml:msup><mml:mo>=</mml:mo><mml:mn>0.007</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, suggesting a potential role of sCD30 in the pathogenesis of AS. However, no significant correlations of sCD30 with BASDAI, ASDAS, or BASFI were detected in our study<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.05</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Therefore, sCD30 cannot be used as a reliable marker for reflecting disease activity and functional ability of AS patients." @default.
• W1641119017 created "2016-06-24" @default.
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• W1641119017 date "2015-01-01" @default.
• W1641119017 modified "2023-09-26" @default.
• W1641119017 title "Elevated Serum Levels of Soluble CD30 in Ankylosing Spondylitis Patients and Its Association with Disease Severity-Related Parameters" @default.
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• W1641119017 doi "https://doi.org/10.1155/2015/617282" @default.
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