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- W1642098659 endingPage "27" @default.
- W1642098659 startingPage "12" @default.
- W1642098659 abstract "As a cell source, multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are promising candidates for chondrogenic differentiation and subsequent cartilage regeneration. From previous literature, it is known that chondrogenic differentiation of MSCs inevitably leads to hypertrophy and subsequent endochondral ossification. In this review, we examine the history of currently established protocols of chondrogenic differentiation and elaborate on the roles of individual components of chondrogenic differentiation medium. We also summarise the effects of physical, chemical and biological factors involved, and propose potential strategies to differentiate MSCs into articular chondrocytes with homogenous mature phenotypes through spatial-temporal incorporation of cell differentiation and chondrogenesis." @default.
- W1642098659 created "2016-06-24" @default.
- W1642098659 creator A5005303316 @default.
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- W1642098659 creator A5038970575 @default.
- W1642098659 creator A5057969219 @default.
- W1642098659 date "2015-07-27" @default.
- W1642098659 modified "2023-10-14" @default.
- W1642098659 title "Evolving concepts of chondrogenic differentiation: history, state-of-the-art and future perspectives" @default.
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