Matches in SemOpenAlex for { <https://semopenalex.org/work/W1642214441> ?p ?o ?g. }
- W1642214441 endingPage "1131" @default.
- W1642214441 startingPage "1120" @default.
- W1642214441 abstract "Factor XIII (FXIII) is activated by thrombin to form a transglutaminase (FXIIIa) that stabilizes clot formation by the cross‐linking of fibrin monomers and antifibrinolytic proteins. Although rare, FXIII deficiency is characterized by variable bleeding manifestations depending on the magnitude of the deficiency. A congenital FXIII deficiency with levels less than 1% can be detected in children who present with prolonged bleeding from the umbilical stump as well as protracted bleeding after trauma. An acquired FXIII deficiency may occur in a number of diseases or clinical situations where FXIII levels and/or its activity are decreased. Patients may also develop a relative deficiency in FXIII as a result of hemorrhage or dilutional changes from transfusions during surgery or trauma and are at increased risk for postoperative bleeding. Genetic studies have identified a wide range of mutations that affect the activity of the FXIII protein but in lieu of molecular genetic analyses, FXIII deficiency can be identified by specific diagnostic assays that measure either the transglutaminase activity of the protein or the levels of the protein and its individual subunits. Replacement therapy has also been shown to increase FXIII levels and reduce bleeding symptoms in patients with congenital FXIII deficiency. This review presents recent findings on the biology of FXIII and the clinical manifestations observed among patients with congenital and acquired FXIII deficiencies." @default.
- W1642214441 created "2016-06-24" @default.
- W1642214441 creator A5024150275 @default.
- W1642214441 creator A5053864173 @default.
- W1642214441 date "2012-08-28" @default.
- W1642214441 modified "2023-10-16" @default.
- W1642214441 title "Biology of Factor XIII and clinical manifestations of Factor XIII deficiency" @default.
- W1642214441 cites W11271216 @default.
- W1642214441 cites W1483765708 @default.
- W1642214441 cites W1495374819 @default.
- W1642214441 cites W1575441707 @default.
- W1642214441 cites W1723482687 @default.
- W1642214441 cites W1766267107 @default.
- W1642214441 cites W1870684347 @default.
- W1642214441 cites W1917366926 @default.
- W1642214441 cites W1962229304 @default.
- W1642214441 cites W1970063984 @default.
- W1642214441 cites W1972469351 @default.
- W1642214441 cites W1973421879 @default.
- W1642214441 cites W1976408668 @default.
- W1642214441 cites W1978135804 @default.
- W1642214441 cites W1982653208 @default.
- W1642214441 cites W1987102104 @default.
- W1642214441 cites W1993009274 @default.
- W1642214441 cites W2000942655 @default.
- W1642214441 cites W2001606735 @default.
- W1642214441 cites W2002813720 @default.
- W1642214441 cites W2002904610 @default.
- W1642214441 cites W2005292580 @default.
- W1642214441 cites W2007142711 @default.
- W1642214441 cites W2008192236 @default.
- W1642214441 cites W2008859628 @default.
- W1642214441 cites W2010004976 @default.
- W1642214441 cites W2011141621 @default.
- W1642214441 cites W2015288130 @default.
- W1642214441 cites W2016941762 @default.
- W1642214441 cites W2021280134 @default.
- W1642214441 cites W2022812773 @default.
- W1642214441 cites W2023354858 @default.
- W1642214441 cites W2035845386 @default.
- W1642214441 cites W2035956989 @default.
- W1642214441 cites W2042298386 @default.
- W1642214441 cites W2042893845 @default.
- W1642214441 cites W2042969679 @default.
- W1642214441 cites W2044124222 @default.
- W1642214441 cites W2045737844 @default.
- W1642214441 cites W2047037435 @default.
- W1642214441 cites W2047900614 @default.
- W1642214441 cites W2051468712 @default.
- W1642214441 cites W2055052286 @default.
- W1642214441 cites W2059391903 @default.
- W1642214441 cites W2060647240 @default.
- W1642214441 cites W2061038774 @default.
- W1642214441 cites W2062173462 @default.
- W1642214441 cites W2064098321 @default.
- W1642214441 cites W2065181902 @default.
- W1642214441 cites W2065421971 @default.
- W1642214441 cites W2068460773 @default.
- W1642214441 cites W2069379572 @default.
- W1642214441 cites W2088781656 @default.
- W1642214441 cites W2090949044 @default.
- W1642214441 cites W2092053993 @default.
- W1642214441 cites W2093119316 @default.
- W1642214441 cites W2093841856 @default.
- W1642214441 cites W2094146154 @default.
- W1642214441 cites W2095204534 @default.
- W1642214441 cites W2095553714 @default.
- W1642214441 cites W2104365341 @default.
- W1642214441 cites W2105288732 @default.
- W1642214441 cites W2108411618 @default.
- W1642214441 cites W2109150694 @default.
- W1642214441 cites W2110541386 @default.
- W1642214441 cites W2123183798 @default.
- W1642214441 cites W2125729104 @default.
- W1642214441 cites W2126105714 @default.
- W1642214441 cites W2128474732 @default.
- W1642214441 cites W2137769523 @default.
- W1642214441 cites W2141024000 @default.
- W1642214441 cites W2152723000 @default.
- W1642214441 cites W2160113023 @default.
- W1642214441 cites W2220542540 @default.
- W1642214441 cites W2325648693 @default.
- W1642214441 cites W2365406070 @default.
- W1642214441 cites W2408494099 @default.
- W1642214441 cites W32567474 @default.
- W1642214441 cites W4241092187 @default.
- W1642214441 cites W4244815965 @default.
- W1642214441 cites W4251451712 @default.
- W1642214441 cites W4302036178 @default.
- W1642214441 cites W47540584 @default.
- W1642214441 cites W77183089 @default.
- W1642214441 doi "https://doi.org/10.1111/j.1537-2995.2012.03865.x" @default.
- W1642214441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22928875" @default.
- W1642214441 hasPublicationYear "2012" @default.
- W1642214441 type Work @default.
- W1642214441 sameAs 1642214441 @default.
- W1642214441 citedByCount "69" @default.
- W1642214441 countsByYear W16422144412013 @default.