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- W164268904 abstract "Environmental exposure to chromium (Cr) is becoming an increasing concern, and certain Cr compounds are recognized as human carcinogens. Chronic use of Cr picolinate has been reported to cause nephrotoxicity in humans if ingested in excess. In addition, it has been reported that Cr picolinate consumption is associated with some acute physiological and behavioral impairment. Chromium supplements have been shown to generate reactive oxygen species (ROS) in cells. Reactive oxygen species are oxygen-containing and highly reactive molecules with unpaired electrons formed during oxidative metabolism. Considerable evidence has shown that ROS play an important role in the initiation of cellular injury, which can lead to the development of cancer. Humans who are exposed to Cr(III) picolinate or other environmentally relevant organic Cr(III) complexes humic acid complexes), are potentially accumulating high levels of Cr(III) in cells. This intracellular accumulation of Cr(III) can result in the formation of covalent bonds between Cr(III) and DNA and/or other macromolecules, causing genotoxic effects." @default.
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- W164268904 date "2007-01-01" @default.
- W164268904 modified "2023-09-26" @default.
- W164268904 title "Overview of chromium(III) toxicology" @default.
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