FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1642814657> ?p ?o ?g. }

• W1642814657 endingPage "6" @default.
• W1642814657 startingPage "1331" @default.
• W1642814657 abstract "The mechanism of action of anticancer chemotherapeutic agents is mainly thought to be due to a direct inhibition of tumor cell proliferation. The enhanced endothelial cell proliferation rate in tumor specimens raised the question of whether therapeutic effects of chemotherapeutic agents might be at least partially attributed to inhibition of tumor angiogenesis. In the present study, we investigated the potential effects of chemotherapeutic agents on human renal carcinoma angiogenesis with the alginate implantation model in mice. For the first time, we also compared results from the angiogenesis model with the inhibitory effects on growth of s.c. xenografts in nude mice. Vincristine and bleomycin exerted strong inhibition of tumor angiogenesis in both carcinoma lines close to the level of the standard antiangiogenic agent O-chloroacetyl-carbamyl-fumagillol (AGM-1470; T/C 22%). Adriamycin reduced angiogenesis of Caki-2 cells (T/C 33%) but had no effect on Caki-1 angiogenesis (T/C 137%). Etoposide and 5-fluorouracil reduced Caki-1 tumor angiogenesis but had no effect on Caki-2. Despite antiangiogenic effects in both carcinoma lines, vincristine, bleomycin, and AGM-1470 significantly reduced only the growth of fast-growing Caki-1 s.c. xenografts but not the slow-growing Caki-2. Antivascular effects by bleomycin and AGM-1470 were also shown by a decrease of microvessel density in nude mouse xenografts. Our findings suggest that chemotherapeutic agents may exert inhibition of tumor angiogenesis, which could be exploitable by combination therapy of fast-growing tumors. The resistance of the slow-growing Caki-2 carcinoma against acute angiogenesis inhibition indicates a need for well-tolerated angiogenesis inhibitors. Our results also suggest the use of fast-growing s.c. xenografts for demonstrating growth inhibition by antiangiogenic compounds. Further characterization of antiangiogenic compounds considered for clinical application should, however, have its focus on slow-growing tumors, which are not accessible for most therapeutic strategies." @default.
• W1642814657 created "2016-06-24" @default.
• W1642814657 creator A5002682008 @default.
• W1642814657 creator A5058926272 @default.
• W1642814657 creator A5062265459 @default.
• W1642814657 creator A5074012897 @default.
• W1642814657 date "1998-05-01" @default.
• W1642814657 modified "2023-09-25" @default.
• W1642814657 title "Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models." @default.
• W1642814657 cites W1483369804 @default.
• W1642814657 cites W1526700228 @default.
• W1642814657 cites W153934429 @default.
• W1642814657 cites W1560264820 @default.
• W1642814657 cites W1825804484 @default.
• W1642814657 cites W1837651204 @default.
• W1642814657 cites W1838918697 @default.
• W1642814657 cites W1965181694 @default.
• W1642814657 cites W1969328947 @default.
• W1642814657 cites W2000688337 @default.
• W1642814657 cites W2010435021 @default.
• W1642814657 cites W2053938092 @default.
• W1642814657 cites W2059620424 @default.
• W1642814657 cites W2070108397 @default.
• W1642814657 cites W2078403575 @default.
• W1642814657 cites W2097628587 @default.
• W1642814657 cites W2102838769 @default.
• W1642814657 cites W2106448082 @default.
• W1642814657 cites W2116751787 @default.
• W1642814657 cites W2138168320 @default.
• W1642814657 cites W2148402970 @default.
• W1642814657 cites W2155056678 @default.
• W1642814657 cites W2155133684 @default.
• W1642814657 cites W2158743409 @default.
• W1642814657 cites W2159957159 @default.
• W1642814657 cites W2164450982 @default.
• W1642814657 cites W2170446694 @default.
• W1642814657 cites W2212388853 @default.
• W1642814657 cites W2264321978 @default.
• W1642814657 cites W2410854081 @default.
• W1642814657 cites W242605141 @default.
• W1642814657 cites W36880404 @default.
• W1642814657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9607594" @default.
• W1642814657 hasPublicationYear "1998" @default.
• W1642814657 type Work @default.
• W1642814657 sameAs 1642814657 @default.
• W1642814657 citedByCount "24" @default.
• W1642814657 countsByYear W16428146572013 @default.
• W1642814657 countsByYear W16428146572017 @default.
• W1642814657 countsByYear W16428146572018 @default.
• W1642814657 countsByYear W16428146572023 @default.
• W1642814657 crossrefType "journal-article" @default.
• W1642814657 hasAuthorship W1642814657A5002682008 @default.
• W1642814657 hasAuthorship W1642814657A5058926272 @default.
• W1642814657 hasAuthorship W1642814657A5062265459 @default.
• W1642814657 hasAuthorship W1642814657A5074012897 @default.
• W1642814657 hasConcept C121608353 @default.
• W1642814657 hasConcept C126322002 @default.
• W1642814657 hasConcept C185592680 @default.
• W1642814657 hasConcept C2776232574 @default.
• W1642814657 hasConcept C2776694085 @default.
• W1642814657 hasConcept C2776755627 @default.
• W1642814657 hasConcept C2779429289 @default.
• W1642814657 hasConcept C2780278673 @default.
• W1642814657 hasConcept C2780394083 @default.
• W1642814657 hasConcept C502942594 @default.
• W1642814657 hasConcept C55493867 @default.
• W1642814657 hasConcept C62112901 @default.
• W1642814657 hasConcept C71924100 @default.
• W1642814657 hasConcept C98274493 @default.
• W1642814657 hasConceptScore W1642814657C121608353 @default.
• W1642814657 hasConceptScore W1642814657C126322002 @default.
• W1642814657 hasConceptScore W1642814657C185592680 @default.
• W1642814657 hasConceptScore W1642814657C2776232574 @default.
• W1642814657 hasConceptScore W1642814657C2776694085 @default.
• W1642814657 hasConceptScore W1642814657C2776755627 @default.
• W1642814657 hasConceptScore W1642814657C2779429289 @default.
• W1642814657 hasConceptScore W1642814657C2780278673 @default.
• W1642814657 hasConceptScore W1642814657C2780394083 @default.
• W1642814657 hasConceptScore W1642814657C502942594 @default.
• W1642814657 hasConceptScore W1642814657C55493867 @default.
• W1642814657 hasConceptScore W1642814657C62112901 @default.
• W1642814657 hasConceptScore W1642814657C71924100 @default.
• W1642814657 hasConceptScore W1642814657C98274493 @default.
• W1642814657 hasIssue "5" @default.
• W1642814657 hasLocation W16428146571 @default.
• W1642814657 hasOpenAccess W1642814657 @default.
• W1642814657 hasPrimaryLocation W16428146571 @default.
• W1642814657 hasRelatedWork W1642814657 @default.
• W1642814657 hasRelatedWork W2014076979 @default.
• W1642814657 hasRelatedWork W2079225881 @default.
• W1642814657 hasRelatedWork W2166766843 @default.
• W1642814657 hasRelatedWork W2293519726 @default.
• W1642814657 hasRelatedWork W2375869434 @default.
• W1642814657 hasRelatedWork W2413586780 @default.
• W1642814657 hasRelatedWork W3097536484 @default.
• W1642814657 hasRelatedWork W3178515596 @default.
• W1642814657 hasRelatedWork W321077955 @default.
• W1642814657 hasVolume "4" @default.

• next