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• W1642829875 abstract "CD4(+) regulatory T cells play a critical role in tolerance induction in transplantation. CD8(+) suppressor T cells have also been shown to control alloimmune responses in preclinical and clinical models. However, the exact nature of the CD8(+) suppressor T cells, their induction and mechanism of function in allogeneic transplantation remain elusive. In this study, we show that functionally suppressive, alloantigen-specific CD8(+) Foxp3(+) T cells can be induced and significantly expanded by stimulating naïve CD8(+) T cells with donor dendritic cells in the presence of IL-2, TGF-β1 and retinoic acid. These CD8(+) Foxp3(+) T cells express enhanced levels of CTLA-4, CCR4 and CD103, inhibit the up-regulation of costimulatory molecules on dendritic cells, and suppress CD4 and CD8 T cell proliferation and cytokine production in a donor-specific and contact-dependent manner. Importantly, upon adoptive transfer, the induced CD8(+) Foxp3(+) T cells protect full MHC-mismatched skin allografts. In vivo, the CD8(+) Foxp3(+) T cells preferentially traffic to the graft draining lymph node where they induce conventional CD4(+) Foxp3(+) T cells and concurrently suppress effector T cell expansion. We conclude that donor-specific CD8(+) Foxp3(+) suppressor T cells can be induced and exploited as an effective form of cell therapy for graft protection in transplantation." @default.
• W1642829875 created "2016-06-24" @default.
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• W1642829875 date "2012-09-01" @default.
• W1642829875 modified "2023-10-14" @default.
• W1642829875 title "Donor-Specific CD8+Foxp3+ T Cells Protect Skin Allografts and Facilitate Induction of Conventional CD4+Foxp3+ Regulatory T Cells" @default.
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• W1642829875 doi "https://doi.org/10.1111/j.1600-6143.2012.04120.x" @default.
• W1642829875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3429694" @default.
• W1642829875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22681667" @default.
• W1642829875 hasPublicationYear "2012" @default.
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