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- W16441074 abstract "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin. During this treatment several hypotheses regarding the modes of action of these drugs were examined. A low serotonin hypothesis was supported by the fact that patients who had pain relief following an acute challenge with fenfluramine, a relatively pure releaser of serotonin, were significantly more likely to have pain relief on either antidepressant. The antidepressants did not change cerebrospinal fluid (CSF) beta-endorphin levels, acute pain tolerance, or electromyogram (EMG) levels. The nonsedating antidepressant desipramine was as effective as doxepin; 60% of patients had significant pain relief. Pain relief was associated with depression relief, but several patients had only pain or depression relief. Patients who had a substantial physical basis for their pain responded as well as those who did not." @default.
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- W16441074 date "1986-09-01" @default.
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- W16441074 title "1986 Volvo Award in Clinical Sciences: Tricyclic Antidepressants for Chronic Low-Back Pain" @default.
- W16441074 doi "https://doi.org/10.1097/00007632-198609000-00003" @default.
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