FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1644283926> ?p ?o ?g. }

• W1644283926 endingPage "892" @default.
• W1644283926 startingPage "S" @default.
• W1644283926 abstract "Background: Stress is a major contributing factor to the pathophysiology of IBS and accelerates colonic transit and increases in defecation. The parasympathetic vagal and pelvic nerves regulate colonic motility and defecation in physiological state. It was shown that physical stress altered colonic functions via vagal efferent in rats. However, it remains still unclear whether the pelvic efferent pathway is involved in accelerating colonic and rectal functions induced by stress. The aim of this study was to investigate whether distal colonic transit and defecation are accelerated via pelvic efferent nerve in psychological stress-loaded rats. We also evaluated the effect of HPA-axis activation on stress -induced defecation. Method: The rats were subjected to water avoidance stress (WAS) or sham stress for 1-hr or 2-hr. The number of fecal pellets was counted for 1-hr in WASor sham stress-rats. Adrenalectomy (Adx), subdiaphragmatic vagotomy (Vag), pelvic nerve rectal branches (Rectal nerves) transection (RNT), or each sham operation was performed at 1 week before WAS. Colonic transit was assessed by the distribution of phenol red injected from catheter located in proximal colon. The distal part of colonic and rectal transit was measured over a 2-hr WAS period from the evacuation rate of a bead inserted into distal colon. c-Fos immunoreactivity (IR), used as a marker of neuronal activation, was monitored in longitudinal muscle/myenteric plexus (LMMP) whole mount preparations of proximal and distal colon after WAS and sham stress. Results: WAS significantly accelerated colorectal transit and defecation with a marked elevation of plasma corticosterone (CORT) levels. Increased defecation induced by WAS was significantly reduced by Vag and RNT, even though CORT levels were elevated. WASinduced acceleration of transit in distal colon and rectum was significantly reduced by RNT, compared with sham-operation. The number of c-Fos-IR cells were significantly increased by WAS in LMMP of proximal and distal colon. In RNTrats, an increase in c-Fos IR cells after WAS was decreased in distal colon, but not in proximal colon, whereas Vag did not affect an increase of c-Fos IR cells in distal colon. In contrast, in Adx-rats WAS increased the number of defecation without an elevation of plasma CORT. Conclusion: It is concluded that psychological stress accelerated distal colonic transit and rectal transit via a parasympathetic efferent pelvic pathway. It seems that the stimulation of pelvic nerve in response to stress activates myenteric neurons in distal colon, followed by an increase of colonic motility. On the other hand, a vagal efferent pathway affects proximal colonic transit. However, an increase in defecation induced by acute psychological stress might not involve the activation of the HPA axis." @default.
• W1644283926 created "2016-06-24" @default.
• W1644283926 creator A5015088085 @default.
• W1644283926 creator A5028208645 @default.
• W1644283926 creator A5038147724 @default.
• W1644283926 creator A5038683663 @default.
• W1644283926 creator A5057974811 @default.
• W1644283926 creator A5061862920 @default.
• W1644283926 creator A5072077099 @default.
• W1644283926 creator A5076050916 @default.
• W1644283926 creator A5082701462 @default.
• W1644283926 creator A5085751036 @default.
• W1644283926 creator A5088834307 @default.
• W1644283926 date "2012-05-01" @default.
• W1644283926 modified "2023-09-24" @default.
• W1644283926 title "Tu1980 Altered Eating Behavior by Subdiaphragmatic Truncal Vagus Nerve Stimulation in Rats" @default.
• W1644283926 doi "https://doi.org/10.1016/s0016-5085(12)63467-2" @default.
• W1644283926 hasPublicationYear "2012" @default.
• W1644283926 type Work @default.
• W1644283926 sameAs 1644283926 @default.
• W1644283926 citedByCount "0" @default.
• W1644283926 crossrefType "journal-article" @default.
• W1644283926 hasAuthorship W1644283926A5015088085 @default.
• W1644283926 hasAuthorship W1644283926A5028208645 @default.
• W1644283926 hasAuthorship W1644283926A5038147724 @default.
• W1644283926 hasAuthorship W1644283926A5038683663 @default.
• W1644283926 hasAuthorship W1644283926A5057974811 @default.
• W1644283926 hasAuthorship W1644283926A5061862920 @default.
• W1644283926 hasAuthorship W1644283926A5072077099 @default.
• W1644283926 hasAuthorship W1644283926A5076050916 @default.
• W1644283926 hasAuthorship W1644283926A5082701462 @default.
• W1644283926 hasAuthorship W1644283926A5085751036 @default.
• W1644283926 hasAuthorship W1644283926A5088834307 @default.
• W1644283926 hasBestOaLocation W16442839261 @default.
• W1644283926 hasConcept C105702510 @default.
• W1644283926 hasConcept C126322002 @default.
• W1644283926 hasConcept C134018914 @default.
• W1644283926 hasConcept C24998067 @default.
• W1644283926 hasConcept C2780087125 @default.
• W1644283926 hasConcept C2781404750 @default.
• W1644283926 hasConcept C71924100 @default.
• W1644283926 hasConceptScore W1644283926C105702510 @default.
• W1644283926 hasConceptScore W1644283926C126322002 @default.
• W1644283926 hasConceptScore W1644283926C134018914 @default.
• W1644283926 hasConceptScore W1644283926C24998067 @default.
• W1644283926 hasConceptScore W1644283926C2780087125 @default.
• W1644283926 hasConceptScore W1644283926C2781404750 @default.
• W1644283926 hasConceptScore W1644283926C71924100 @default.
• W1644283926 hasIssue "5" @default.
• W1644283926 hasLocation W16442839261 @default.
• W1644283926 hasOpenAccess W1644283926 @default.
• W1644283926 hasPrimaryLocation W16442839261 @default.
• W1644283926 hasRelatedWork W1984619393 @default.
• W1644283926 hasRelatedWork W2034768996 @default.
• W1644283926 hasRelatedWork W2054992011 @default.
• W1644283926 hasRelatedWork W2060618991 @default.
• W1644283926 hasRelatedWork W2064416809 @default.
• W1644283926 hasRelatedWork W2094219890 @default.
• W1644283926 hasRelatedWork W2163700154 @default.
• W1644283926 hasRelatedWork W2226562228 @default.
• W1644283926 hasRelatedWork W2899224757 @default.
• W1644283926 hasRelatedWork W1996741910 @default.
• W1644283926 hasVolume "142" @default.
• W1644283926 isParatext "false" @default.
• W1644283926 isRetracted "false" @default.
• W1644283926 magId "1644283926" @default.
• W1644283926 workType "article" @default.