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• W1644294911 abstract "Abstract Acute rejection is mediated by T cell infiltration of allografts, but mechanisms mediating the delayed rejection of allografts in chemokine receptor-deficient recipients remain unclear. The rejection of vascularized, MHC-mismatched cardiac allografts by CCR5−/− recipients was investigated. Heart grafts from A/J (H-2a) donors were rejected by wild-type C57BL/6 (H-2b) recipients on day 8–10 posttransplant vs day 8–11 by CCR5−/− recipients. When compared with grafts from wild-type recipients, however, significant decreases in CD4+ and CD8+ T cells and macrophages were observed in rejecting allografts from CCR5-deficient recipients. These decreases were accompanied by significantly lower numbers of alloreactive T cells developing to IFN-γ-, but not IL-4-producing cells in the CCR5−/− recipients, suggesting suboptimal priming of T cells in the knockout recipients. CCR5 was more prominently expressed on activated CD4+ than CD8+ T cells in the spleens of allograft wild-type recipients and on CD4+ T cells infiltrating the cardiac allografts. Rejecting cardiac allografts from wild-type recipients had low level deposition of C3d that was restricted to the graft vessels. Rejecting allografts from CCR5−/− recipients had intense C3d deposition in the vessels as well as on capillaries throughout the graft parenchyma similar to that observed during rejection in donor-sensitized recipients. Titers of donor-reactive Abs in the serum of CCR5−/− recipients were almost 20-fold higher than those induced in wild-type recipients, and the high titers appeared as early as day 6 posttransplant. These results suggest dysregulation of alloreactive Ab responses and Ab-mediated cardiac allograft rejection in the absence of recipient CCR5." @default.
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• W1644294911 date "2005-05-15" @default.
• W1644294911 modified "2023-10-17" @default.
• W1644294911 title "Absence of Recipient CCR5 Promotes Early and Increased Allospecific Antibody Responses to Cardiac Allografts" @default.
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• W1644294911 doi "https://doi.org/10.4049/jimmunol.174.10.6499" @default.
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