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• W1644727092 abstract "Mechanical interaction between cancer cells and their microenvironment plays a central role in the progression of tumors. In vitro models based on biopolymer networks have been successfully employed to simulate the 3D extracellular matrix (ECM) of tumors. In this review, we focus on type I collagen gel. We describe the hierarchical structural and mechanical properties of type I collagen ECM. We demonstrate that corresponding to the scales of adhesion sites, single cells and cell colonies, the mechanics of the ECM is dominated by single fibers, fiber clusters and rheology of the whole fiber network. In the end, we discuss the limitations of reconstituted type I collagen as in vitro ECM. 关键词:癌细胞,弹性模量,胶原蛋白,微环境 Keyword: cancer cell, elastic modulus, collagen, microenvironment PACS:82.35.Pq, 87.14.em, 87.19.xj,87.16.dm † 通讯作者.E-mail: sunb@physics.oregonstate.edu 电话:1-541-737-8203 1 引 言 癌细胞的微环境是近年来肿瘤研究的热点方向。越来越多的证据表明,肿瘤的形 成,发展和扩散并不是癌细胞独立的行为 (Balkwill, et al., 2012; Allinen, et al., 2004; Friedl & Alexander, 2011; Hanahan & Weinberg, 2000)。细胞 外介质中的各种可溶性生长因子 (Bierie & Moses, 2006),其他细胞分泌释放的 物质 (例如微 RNA (Muhammad, 2014; Soon & Kiaris, 2013)),以及其他种类 的细胞 (Zigrino, et al., 2005; Hua, et al., 2007)都起着直接或间接的作用。 而区别于这些生物化学因素的,是细胞外介质的力学特性 (Ulrich, et al., 2009; Yeung, et al., 2005)。机体力学特性的变化是肿瘤的常见表征之一。以 乳癌为例,癌变组织的弹性模量可以达到正常乳房的 10倍以上 (Lopez, et al., 2011)。这种变化的影响是双向的。一方面,癌细胞力学微环境特性会影响肿瘤的 生理学,增加癌细胞的运动和生长速率,甚至于促进癌细胞转变为更加危险的表 型(phenotype) (Dingal & Discher, 2014; Seewaldt, 2014; Bordeleau, et al., 2014)。 另一方面,肿瘤的发展通常主动伴随着其力学微环境的改变。仍以 乳癌为例,与癌细胞密切相关的 TGF-β生长因子可以激活 fibroblast细胞分泌 过多的胶原纤维,导致乳房密度和硬度的增加 (Barcellos-Hoff & Ravani," @default.
• W1644727092 created "2016-06-24" @default.
• W1644727092 creator A5034916569 @default.
• W1644727092 date "2015-01-01" @default.
• W1644727092 modified "2023-09-27" @default.
• W1644727092 title "Collagen network and the mechanical microenvironment of cancer cells" @default.
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• W1644727092 doi "https://doi.org/10.7498/aps.64.058201" @default.
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