FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1644751088> ?p ?o ?g. }

• W1644751088 endingPage "1004" @default.
• W1644751088 startingPage "998" @default.
• W1644751088 abstract "Abstract Activation of naive CD8 T cells in vitro in the presence of IL-4 induces type 2 cytokine expression, loss of CD8 expression, and reduced cytolytic potential. This represents a major shift from the canonical phenotype of effector CD8 T cells. It has not been established, however, whether IL-4 can induce comprehensive type 2 cytokine expression by CD8 T cells in vivo, nor whether the effects of IL-4 on type 2 cytokine production by CD8 T cells can be inhibited by IFN-γ. Furthermore, disparate results have been reported regarding the anti-tumor ability of type 2 polarized effector CD8 T cells, and the effects of IFN-γ in this respect remain unknown. To address these questions, wild-type or IFN-γ–deficient OVA-specific CD8+ T cells were activated in RAG-2−/− γc−/− recipients with control or IL-4–expressing OVA+ tumor cells, and then transferred to secondary recipients for tumor challenge. Tumor-derived IL-4 induced the expression of type 2 cytokines and the transcription factor GATA-3 by responding CD8 T cells while reducing their CD8 coreceptor expression and ability to eliminate a secondary tumor challenge. Each of these effects of IL-4 was exaggerated in IFN-γ–deficient, compared with wild-type, CD8 T cells. The results demonstrate that endogenous IFN-γ counteracts the induction of type 2 cytokines and the downregulation of both CD8 coreceptor levels and the anti-tumor response in CD8 T cells exposed to IL-4 during activation in vivo. These findings may explain the anomalies in the reported functional phenotype of type 2 polarized CD8 T cells." @default.
• W1644751088 created "2016-06-24" @default.
• W1644751088 creator A5000162705 @default.
• W1644751088 creator A5028014361 @default.
• W1644751088 creator A5054666772 @default.
• W1644751088 creator A5056729267 @default.
• W1644751088 creator A5074117354 @default.
• W1644751088 creator A5080747464 @default.
• W1644751088 creator A5087303099 @default.
• W1644751088 date "2010-07-15" @default.
• W1644751088 modified "2023-10-04" @default.
• W1644751088 title "IFN-γ Inhibits IL-4–Induced Type 2 Cytokine Expression by CD8 T Cells In Vivo and Modulates the Anti-Tumor Response" @default.
• W1644751088 cites W1533882621 @default.
• W1644751088 cites W1817153273 @default.
• W1644751088 cites W1891716637 @default.
• W1644751088 cites W1909678629 @default.
• W1644751088 cites W1941785397 @default.
• W1644751088 cites W1944190464 @default.
• W1644751088 cites W1965410838 @default.
• W1644751088 cites W1979657237 @default.
• W1644751088 cites W1980060543 @default.
• W1644751088 cites W2011754426 @default.
• W1644751088 cites W2027699993 @default.
• W1644751088 cites W2031482359 @default.
• W1644751088 cites W2038592860 @default.
• W1644751088 cites W2040887800 @default.
• W1644751088 cites W2044531251 @default.
• W1644751088 cites W2060406376 @default.
• W1644751088 cites W2077825191 @default.
• W1644751088 cites W2090279685 @default.
• W1644751088 cites W2090896399 @default.
• W1644751088 cites W2091508129 @default.
• W1644751088 cites W2095294902 @default.
• W1644751088 cites W2099180944 @default.
• W1644751088 cites W2106183372 @default.
• W1644751088 cites W2127100845 @default.
• W1644751088 cites W2134282290 @default.
• W1644751088 cites W2141507915 @default.
• W1644751088 cites W2144122733 @default.
• W1644751088 cites W2147391813 @default.
• W1644751088 cites W2150234999 @default.
• W1644751088 cites W2163113523 @default.
• W1644751088 cites W4235204700 @default.
• W1644751088 doi "https://doi.org/10.4049/jimmunol.0903372" @default.
• W1644751088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20562261" @default.
• W1644751088 hasPublicationYear "2010" @default.
• W1644751088 type Work @default.
• W1644751088 sameAs 1644751088 @default.
• W1644751088 citedByCount "36" @default.
• W1644751088 countsByYear W16447510882012 @default.
• W1644751088 countsByYear W16447510882013 @default.
• W1644751088 countsByYear W16447510882014 @default.
• W1644751088 countsByYear W16447510882015 @default.
• W1644751088 countsByYear W16447510882017 @default.
• W1644751088 countsByYear W16447510882018 @default.
• W1644751088 countsByYear W16447510882019 @default.
• W1644751088 countsByYear W16447510882020 @default.
• W1644751088 countsByYear W16447510882021 @default.
• W1644751088 countsByYear W16447510882022 @default.
• W1644751088 countsByYear W16447510882023 @default.
• W1644751088 crossrefType "journal-article" @default.
• W1644751088 hasAuthorship W1644751088A5000162705 @default.
• W1644751088 hasAuthorship W1644751088A5028014361 @default.
• W1644751088 hasAuthorship W1644751088A5054666772 @default.
• W1644751088 hasAuthorship W1644751088A5056729267 @default.
• W1644751088 hasAuthorship W1644751088A5074117354 @default.
• W1644751088 hasAuthorship W1644751088A5080747464 @default.
• W1644751088 hasAuthorship W1644751088A5087303099 @default.
• W1644751088 hasBestOaLocation W16447510881 @default.
• W1644751088 hasConcept C150903083 @default.
• W1644751088 hasConcept C153911025 @default.
• W1644751088 hasConcept C154317977 @default.
• W1644751088 hasConcept C167672396 @default.
• W1644751088 hasConcept C202751555 @default.
• W1644751088 hasConcept C203014093 @default.
• W1644751088 hasConcept C207001950 @default.
• W1644751088 hasConcept C2778690821 @default.
• W1644751088 hasConcept C502942594 @default.
• W1644751088 hasConcept C51785407 @default.
• W1644751088 hasConcept C55493867 @default.
• W1644751088 hasConcept C86803240 @default.
• W1644751088 hasConcept C8891405 @default.
• W1644751088 hasConcept C95444343 @default.
• W1644751088 hasConceptScore W1644751088C150903083 @default.
• W1644751088 hasConceptScore W1644751088C153911025 @default.
• W1644751088 hasConceptScore W1644751088C154317977 @default.
• W1644751088 hasConceptScore W1644751088C167672396 @default.
• W1644751088 hasConceptScore W1644751088C202751555 @default.
• W1644751088 hasConceptScore W1644751088C203014093 @default.
• W1644751088 hasConceptScore W1644751088C207001950 @default.
• W1644751088 hasConceptScore W1644751088C2778690821 @default.
• W1644751088 hasConceptScore W1644751088C502942594 @default.
• W1644751088 hasConceptScore W1644751088C51785407 @default.
• W1644751088 hasConceptScore W1644751088C55493867 @default.
• W1644751088 hasConceptScore W1644751088C86803240 @default.
• W1644751088 hasConceptScore W1644751088C8891405 @default.
• W1644751088 hasConceptScore W1644751088C95444343 @default.
• W1644751088 hasIssue "2" @default.

• next