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• W1644965934 abstract "The period of time research in the field of drug metabolism has been intense and many properties of the enzymes involved have been revealed. These include their distribution between different tissues and their subcellular localization, and important aspects of their reaction mechanisms and regulation. During the past few years, drug metabolism as a whole has attracted increasing attention and has developed from being regarded as a number of odd reactions to its present status as being of considerable physiological and medical importance. At the same time, the overall view on drug metabolism as being almost entirely a detoxication mechanism has changed, and it is now widely accepted that this enzymatic process sometimes give rise to toxic, mutagenic, or carcinogenic products. The chapter explains the field of drug metabolism with special regard to the properties and reaction mechanisms of cytochrome P-4 50-linked reactions. Cytochrome P-450-catalyzed drug mono-oxygenation is only a link in a chain of reactions resulting in the conversion of a lipid soluble drug to a more polar, excretable product. Drug metabolism often involves a complex interplay between a number of enzymatic processes where cytochrome P-450-linked mono-oxygenation, however, occupies a central role and frequently seems to be rate limiting for overall drug biotransformation." @default.
• W1644965934 created "2016-06-24" @default.
• W1644965934 creator A5084588481 @default.
• W1644965934 date "1976-01-01" @default.
• W1644965934 modified "2023-10-01" @default.
• W1644965934 title "REACTION MECHANISMS OF CYTOCHROME P-450" @default.
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• W1644965934 doi "https://doi.org/10.1016/b978-0-08-020544-1.50010-8" @default.
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