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- W1644991946 abstract "Myeloperoxidase, a heme protein secreted by activated phagocytes, is expressed in human atherosclerotic lesions. The enzyme uses H2O2 generated by the cells to oxidize L-tyrosine to tyrosyl radical, a catalyst for protein dityrosine synthesis. We have explored the possibility that tyrosyl radical initiates lipid peroxidation, which may be of pivotal importance in transforming low density lipoprotein (LDL) into atherogenic particles. Exposure of LDL to L-tyrosine and activated human neutrophils caused peroxidation of LDL lipids. LDL oxidation required L-tyrosine but was independent of free metal ions; catalase and heme poisons were inhibitory. Incubation of LDL with L-tyrosine, myeloperoxidase, and H2O2 likewise caused lipid peroxidation, and this reaction was inhibited by heme poisons and catalase. Replacement of L-tyrosine with O-methyltyrosine, which cannot form tyrosyl radical, inhibited LDL oxidation by both activated neutrophils and myeloperoxidase. The antioxidants ascorbate and probucol, but not vitamin E, inhibited LDL oxidation by myeloperoxidase, H2O2, and L-tyrosine. Ascorbate blocked dityrosine synthesis, while probucol scavenged chain-propagating peroxyl radicals in the lipid phase of LDL. These results indicate that tyrosyl radical stimulates LDL lipid peroxidation. In striking contrast to other cell-mediated mechanisms for LDL oxidation, the myeloperoxidase-catalyzed reaction is independent of free metal ions. This raises the possibility that tyrosyl radical generated by myeloperoxidase is of physiological importance in making LDL atherogenic." @default.
- W1644991946 created "2016-06-24" @default.
- W1644991946 creator A5035595391 @default.
- W1644991946 creator A5056338732 @default.
- W1644991946 creator A5088562850 @default.
- W1644991946 date "1994-08-01" @default.
- W1644991946 modified "2023-10-14" @default.
- W1644991946 title "Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein." @default.
- W1644991946 cites W1485321383 @default.
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- W1644991946 cites W1505149221 @default.
- W1644991946 cites W1523652295 @default.
- W1644991946 cites W1525444530 @default.
- W1644991946 cites W1531513729 @default.
- W1644991946 cites W1534702626 @default.
- W1644991946 cites W1536422318 @default.
- W1644991946 cites W1562522900 @default.
- W1644991946 cites W1572331504 @default.
- W1644991946 cites W1608651134 @default.
- W1644991946 cites W1633178688 @default.
- W1644991946 cites W1747737458 @default.
- W1644991946 cites W1775749144 @default.
- W1644991946 cites W1824744945 @default.
- W1644991946 cites W1841006369 @default.
- W1644991946 cites W1845299120 @default.
- W1644991946 cites W1890547526 @default.
- W1644991946 cites W193604910 @default.
- W1644991946 cites W1964848918 @default.
- W1644991946 cites W1965340455 @default.
- W1644991946 cites W1969878412 @default.
- W1644991946 cites W1970185441 @default.
- W1644991946 cites W1972182067 @default.
- W1644991946 cites W1974452675 @default.
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- W1644991946 cites W1979281692 @default.
- W1644991946 cites W1980108198 @default.
- W1644991946 cites W1985461884 @default.
- W1644991946 cites W1990468555 @default.
- W1644991946 cites W1994259078 @default.
- W1644991946 cites W1997785022 @default.
- W1644991946 cites W2000548860 @default.
- W1644991946 cites W2003240217 @default.
- W1644991946 cites W2003897562 @default.
- W1644991946 cites W2005230846 @default.
- W1644991946 cites W2005910570 @default.
- W1644991946 cites W2017315967 @default.
- W1644991946 cites W2019910161 @default.
- W1644991946 cites W2022321693 @default.
- W1644991946 cites W2023122744 @default.
- W1644991946 cites W2036852690 @default.
- W1644991946 cites W2038896155 @default.
- W1644991946 cites W2039042657 @default.
- W1644991946 cites W2040579726 @default.
- W1644991946 cites W2040844673 @default.
- W1644991946 cites W2043756056 @default.
- W1644991946 cites W2045096999 @default.
- W1644991946 cites W2046382167 @default.
- W1644991946 cites W2048039428 @default.
- W1644991946 cites W2049401036 @default.
- W1644991946 cites W2055111376 @default.
- W1644991946 cites W2059543443 @default.
- W1644991946 cites W2061123740 @default.
- W1644991946 cites W2061242359 @default.
- W1644991946 cites W2079735654 @default.
- W1644991946 cites W2081304820 @default.
- W1644991946 cites W2089772634 @default.
- W1644991946 cites W2091037241 @default.
- W1644991946 cites W2104573407 @default.
- W1644991946 cites W2109173122 @default.
- W1644991946 cites W2112698709 @default.
- W1644991946 cites W2113553969 @default.
- W1644991946 cites W2116371832 @default.
- W1644991946 cites W2117966002 @default.
- W1644991946 cites W2121972309 @default.
- W1644991946 cites W2140328938 @default.
- W1644991946 cites W2151840391 @default.
- W1644991946 cites W2154658221 @default.
- W1644991946 cites W2154760942 @default.
- W1644991946 cites W2158604239 @default.
- W1644991946 cites W2161165626 @default.
- W1644991946 cites W2212323528 @default.
- W1644991946 cites W2224459702 @default.
- W1644991946 cites W2894728782 @default.
- W1644991946 cites W3023000517 @default.
- W1644991946 cites W4211045023 @default.
- W1644991946 cites W4214589643 @default.
- W1644991946 cites W4379136709 @default.
- W1644991946 doi "https://doi.org/10.1016/s0021-9258(17)32005-7" @default.
- W1644991946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8051134" @default.
- W1644991946 hasPublicationYear "1994" @default.
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