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- W164501941 startingPage "690" @default.
- W164501941 abstract "This chapter describes a study to examine the use of botulinum toxin and α-Bungarotoxin. An assay system for depolarization-evoked ACh release was developed using purified synaptosomes from guinea pig cerebral cortices. The synaptosomes, suspended in physiological medium, were loaded with 14C-choline and 65% of the accumulated 14C-choline was converted to 14C-ACh. At the neuromuscular junction in vitro, botulinum toxin displays a similar slow development of its inhibitory action, the time course being dependent upon toxin concentration. The toxin is rapidly fixed by the nerve ending because the nerve muscle preparation can be washed after a short exposure to the toxin without diminishing the subsequent development of inhibition. Iodinated botulinum toxin was shown to bind to synaptosomes, but these observations were not correlated with any physiological action of the toxin. The time course of binding to synaptosomes was examined indirectly by eliminating free toxin by washing at intervals during the preincubation period. The preincubation was continued for a total time of 1 h before assaying 14C-ACh release. The time course of binding is very different from the time course of inhibition and maximum inhibition ultimately results after only 10 or 15 min exposure to the toxin." @default.
- W164501941 created "2016-06-24" @default.
- W164501941 creator A5025249043 @default.
- W164501941 date "1980-01-01" @default.
- W164501941 modified "2023-10-14" @default.
- W164501941 title "THE USE OF NEUROTOXINS IN NEUROBIOLOGY: STUDIES WITH BOTULINUM TOXIN AND α-BUNGAROTOXIN" @default.
- W164501941 cites W1439153856 @default.
- W164501941 cites W1487867291 @default.
- W164501941 cites W1525268213 @default.
- W164501941 cites W1550077015 @default.
- W164501941 cites W1591133750 @default.
- W164501941 cites W1604077926 @default.
- W164501941 cites W1881955275 @default.
- W164501941 cites W1941904860 @default.
- W164501941 cites W1956108555 @default.
- W164501941 cites W1967362482 @default.
- W164501941 cites W1969719530 @default.
- W164501941 cites W1969795802 @default.
- W164501941 cites W1973479287 @default.
- W164501941 cites W1976730928 @default.
- W164501941 cites W197760010 @default.
- W164501941 cites W1980234010 @default.
- W164501941 cites W1981564602 @default.
- W164501941 cites W1984337870 @default.
- W164501941 cites W1992680430 @default.
- W164501941 cites W1993018077 @default.
- W164501941 cites W1996304459 @default.
- W164501941 cites W1996421895 @default.
- W164501941 cites W1996497544 @default.
- W164501941 cites W1997194897 @default.
- W164501941 cites W1998132488 @default.
- W164501941 cites W2000404605 @default.
- W164501941 cites W2002142711 @default.
- W164501941 cites W2003649749 @default.
- W164501941 cites W2004213389 @default.
- W164501941 cites W2005878720 @default.
- W164501941 cites W2007348859 @default.
- W164501941 cites W2007809819 @default.
- W164501941 cites W2014138752 @default.
- W164501941 cites W2015267452 @default.
- W164501941 cites W2015411378 @default.
- W164501941 cites W2015905038 @default.
- W164501941 cites W2016641890 @default.
- W164501941 cites W2018170523 @default.
- W164501941 cites W2018555602 @default.
- W164501941 cites W2022886311 @default.
- W164501941 cites W2024324577 @default.
- W164501941 cites W2024911162 @default.
- W164501941 cites W2025747841 @default.
- W164501941 cites W2026278523 @default.
- W164501941 cites W2027122153 @default.
- W164501941 cites W2028529472 @default.
- W164501941 cites W2028840946 @default.
- W164501941 cites W2031102676 @default.
- W164501941 cites W2032527931 @default.
- W164501941 cites W2034606843 @default.
- W164501941 cites W2035247577 @default.
- W164501941 cites W2035877294 @default.
- W164501941 cites W2036087987 @default.
- W164501941 cites W2036265755 @default.
- W164501941 cites W2037209406 @default.
- W164501941 cites W2037582982 @default.
- W164501941 cites W2037900307 @default.
- W164501941 cites W2038167291 @default.
- W164501941 cites W2043082195 @default.
- W164501941 cites W2044421155 @default.
- W164501941 cites W2050652580 @default.
- W164501941 cites W2050833857 @default.
- W164501941 cites W2050979634 @default.
- W164501941 cites W2051108806 @default.
- W164501941 cites W2052369869 @default.
- W164501941 cites W2052688087 @default.
- W164501941 cites W2053413143 @default.
- W164501941 cites W2054832451 @default.
- W164501941 cites W2055787540 @default.
- W164501941 cites W2056127635 @default.
- W164501941 cites W2062521762 @default.
- W164501941 cites W2064313207 @default.
- W164501941 cites W2064604852 @default.
- W164501941 cites W2066174991 @default.
- W164501941 cites W2070019098 @default.
- W164501941 cites W2073867566 @default.
- W164501941 cites W2075692390 @default.
- W164501941 cites W2076359725 @default.
- W164501941 cites W2078068750 @default.
- W164501941 cites W2082509431 @default.
- W164501941 cites W2084911385 @default.
- W164501941 cites W2091740545 @default.
- W164501941 cites W2093374872 @default.
- W164501941 cites W2093375448 @default.
- W164501941 cites W2093804401 @default.
- W164501941 cites W2106687345 @default.
- W164501941 cites W2118902835 @default.
- W164501941 cites W2124685534 @default.
- W164501941 cites W2125213900 @default.
- W164501941 cites W2134218003 @default.
- W164501941 cites W2156583208 @default.
- W164501941 cites W2275222709 @default.