FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W164534757> ?p ?o ?g. }

• W164534757 endingPage "7" @default.
• W164534757 startingPage "15" @default.
• W164534757 abstract "Oral cancer accounts for 40 to 50% of cancers diagnosed in India. Oral cancer is preceeded in most cases by pre malignant lesions-leukoplakia, submucous fibrosis and lichen planus. Stoppage of causative agents reverts premalignant lesions in some of the cases only. Thus anti oxidant therapy is being used to revert premalignant change to normal. Few studies available, have taken clinical parameters as indicators of response to therapy. Extensive medline search failed to reveal any study at the cellular level. This study attempts to investigate for the first time the role of p53 and bcl2 as markers of prognosis following vitamin A therapy. 24 cases of pre malignant lesions of oral cavity were studied. 1 lakh IU of vitamin A were given orally twice a week for 3 months. Biopsies were done before and after therapy. Haematoxylin and Eosin stain was done to confirm diagnosis. Immunostaining for mutant p53 and bcl2 was done on paraffin sections. 500 cells were counted over an average of 5 HPF and percentage positivity was calculated. Statistical analysis was done by applying the paired t tests. In 19 cases (79.2%) of premalignant lesions mutant p53 expression was zero before therapy, and remained unchanged even after the therapy. 3 cases (12.5%) had high mutant p53 values which reduced following therapy (p = 0.037). Therapy thus proved effective in these cases. However, in 2 cases (8.3%) pre therapy values of zero showed an increase after vitamin A therapy. These were the cases which had dysplasia and were chronic smokers. In 2 cases (8.3%) pre therapy values of bcl2 were zero and remained unchanged even after therapy and these cases did not stop smoking even during the vitamin A therapy. In 12 cases (50.0%) higher pre therapy values were reduced after therapy (p < 0.0001). Vitamin A therapy was effective in these cases. However, in 10 cases (42.0%) expression of bcl2 increased subsequent to therapy. Therapy failed in these cases because of chronic heavy smoking and tobacco chewing. Thus, in the majority of cases vitamin A was effective in preventing mutation of p53 (91.7%) and expression of bcl2 (58.0%). In effect, these two oncoproteins can be used as prognostic markers and follow up for anti oxidant therapy." @default.
• W164534757 created "2016-06-24" @default.
• W164534757 creator A5018637895 @default.
• W164534757 creator A5039465203 @default.
• W164534757 creator A5057981101 @default.
• W164534757 date "2007-01-01" @default.
• W164534757 modified "2023-09-23" @default.
• W164534757 title "Role of p53 and bcl2 as markers of vitamin A response in premalignant lesions of the oral cavity." @default.
• W164534757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17474247" @default.
• W164534757 hasPublicationYear "2007" @default.
• W164534757 type Work @default.
• W164534757 sameAs 164534757 @default.
• W164534757 citedByCount "2" @default.
• W164534757 countsByYear W1645347572018 @default.
• W164534757 crossrefType "journal-article" @default.
• W164534757 hasAuthorship W164534757A5018637895 @default.
• W164534757 hasAuthorship W164534757A5039465203 @default.
• W164534757 hasAuthorship W164534757A5057981101 @default.
• W164534757 hasConcept C121608353 @default.
• W164534757 hasConcept C126322002 @default.
• W164534757 hasConcept C142724271 @default.
• W164534757 hasConcept C2775894508 @default.
• W164534757 hasConcept C2777550702 @default.
• W164534757 hasConcept C2780672762 @default.
• W164534757 hasConcept C71924100 @default.
• W164534757 hasConcept C90924648 @default.
• W164534757 hasConceptScore W164534757C121608353 @default.
• W164534757 hasConceptScore W164534757C126322002 @default.
• W164534757 hasConceptScore W164534757C142724271 @default.
• W164534757 hasConceptScore W164534757C2775894508 @default.
• W164534757 hasConceptScore W164534757C2777550702 @default.
• W164534757 hasConceptScore W164534757C2780672762 @default.
• W164534757 hasConceptScore W164534757C71924100 @default.
• W164534757 hasConceptScore W164534757C90924648 @default.
• W164534757 hasIssue "1" @default.
• W164534757 hasLocation W1645347571 @default.
• W164534757 hasOpenAccess W164534757 @default.
• W164534757 hasPrimaryLocation W1645347571 @default.
• W164534757 hasRelatedWork W1968751856 @default.
• W164534757 hasRelatedWork W2003627314 @default.
• W164534757 hasRelatedWork W2031086342 @default.
• W164534757 hasRelatedWork W2066460184 @default.
• W164534757 hasRelatedWork W2115586876 @default.
• W164534757 hasRelatedWork W2145093287 @default.
• W164534757 hasRelatedWork W2184264088 @default.
• W164534757 hasRelatedWork W2253284839 @default.
• W164534757 hasRelatedWork W2338006471 @default.
• W164534757 hasRelatedWork W2375250700 @default.
• W164534757 hasRelatedWork W2406391501 @default.
• W164534757 hasRelatedWork W2408135209 @default.
• W164534757 hasRelatedWork W2416184303 @default.
• W164534757 hasRelatedWork W2426387789 @default.
• W164534757 hasRelatedWork W2466058063 @default.
• W164534757 hasRelatedWork W2789423409 @default.
• W164534757 hasRelatedWork W2987336262 @default.
• W164534757 hasRelatedWork W2988414973 @default.
• W164534757 hasRelatedWork W3142730539 @default.
• W164534757 hasRelatedWork W2346509597 @default.
• W164534757 hasVolume "50" @default.
• W164534757 isParatext "false" @default.
• W164534757 isRetracted "false" @default.
• W164534757 magId "164534757" @default.
• W164534757 workType "article" @default.