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• W1645352334 endingPage "2082" @default.
• W1645352334 startingPage "2074" @default.
• W1645352334 abstract "Abstract The NF-κB family of transcription factors forms one of the first lines of defense against infectious disease by inducing the expression of genes involved in inflammatory and immune responses. In this study, we analyzed the impact of Shiga toxin-producing Escherichia coli (STEC) on the NF-κB DNA-binding activity in HeLa cells. After a period of weak initial activation, DNA binding of NF-κB was actively suppressed by viable, E. coli secreted protein B (EspB)-secreting STEC. Sustained NF-κB activity was observed either using an isogenic mutant lacking EspB or after gentamicin-based killing of STEC after allowing bacterial attachment. These observations indicate that the ability of STEC to cause NF-κB activation is suppressed by a translocated bacterial effector protein, which is either EspB itself or requires EspB for delivery into the host cell. We found that STEC, enterohemorrhagic E. coli, and enteropathogenic E. coli all interfere with NF-κB activation initiated by TNF-α, indicating that suppression of signal-induced NF-κB activity is a property common to several attaching and effacing bacteria. As a consequence of NF-κB suppression, wild-type STEC induces significantly lower mRNA levels of IL-8, IL-6, and IL-1α upon prolonged infection periods compared with bacteria lacking EspB. For IL-8 and IL-6, the suppressive effect was also reflected at the level of cytokine secretion. Suppression of both basal and signal-induced NF-κB DNA binding by attaching and effacing-inducing bacteria appears to be an active strategy to counteract host defense responses, thus favoring intestinal colonization by these pathogens." @default.
• W1645352334 created "2016-06-24" @default.
• W1645352334 creator A5053076250 @default.
• W1645352334 creator A5061655044 @default.
• W1645352334 date "2003-02-15" @default.
• W1645352334 modified "2023-09-23" @default.
• W1645352334 title "Suppression of NF-κB Activation and Proinflammatory Cytokine Expression by Shiga Toxin-Producing <i>Escherichia coli</i>" @default.
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• W1645352334 doi "https://doi.org/10.4049/jimmunol.170.4.2074" @default.
• W1645352334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12574378" @default.
• W1645352334 hasPublicationYear "2003" @default.
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