Matches in SemOpenAlex for { <https://semopenalex.org/work/W1645397737> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W1645397737 endingPage "67" @default.
- W1645397737 startingPage "58" @default.
- W1645397737 abstract "Immunochemical methods, methods that employ antibodies as analytical reagents, have revolutionized laboratory medicine. Although the noncovalent bound between analyte in biological specimen and complementary antibody in reagent is specific, positive or negative interferences are possible. Interfering substances can be present in both specimen and reagents, respectively. Most interfering substances are inherent in patients’ blood under physiological and pathophysiological conditions, especially under diagnostic and therapeutic procedures. Some interferences are similar to those in chemical analyses and some are typical only for immunoassays (hook effect ; cross-reactivity with structurally similar or identical epitopes ; heterophile antibodies ; anti-animal antibodies ; autoantibodies ; the matrix effect). The main characteristic of all immunoassays is that the reagent which discovers or quantifies the target analyte contains the specific antibody. Results higher than real values are recorded due to a low antibody specificity. Results can also be influenced by pre-analytical factors or assay formulations. One should suspect interferences a) after obtaining an unacceptable result ; b) if there is non-linearity during dilution ; c) if there is no agreement with other test results or clinical data ; d) if different immunoassays in determination of the same analyte provide significantly different results. It is necessary to think about present predictable and always possible unpredictable and unrecognizable interferences. Unawareness and non-recognition of interferences could lead to diagnostic errors, unnecessary laboratory tests, inadequate and unnecessary treatment and therapy. There is no simple and practical way to identify interferences in specimens before analysis. Whenever interference is suspected, there are a few possibilities to solve them, e.g. serial dilution, pre-treatment with blocking reagent, use of more specific methods. At the same time a proper information upon pre-analytical diagnostic and therapeutic procedures is needed for accurate interpretation of the results. In this process, consistent communication and compliance between laboratory professionals and clinicians are required." @default.
- W1645397737 created "2016-06-24" @default.
- W1645397737 creator A5074708440 @default.
- W1645397737 date "2012-05-16" @default.
- W1645397737 modified "2023-09-27" @default.
- W1645397737 title "Interferences in Immunochemical Methods" @default.
- W1645397737 hasPublicationYear "2012" @default.
- W1645397737 type Work @default.
- W1645397737 sameAs 1645397737 @default.
- W1645397737 citedByCount "0" @default.
- W1645397737 crossrefType "journal-article" @default.
- W1645397737 hasAuthorship W1645397737A5074708440 @default.
- W1645397737 hasConcept C10390740 @default.
- W1645397737 hasConcept C121332964 @default.
- W1645397737 hasConcept C127162648 @default.
- W1645397737 hasConcept C147789679 @default.
- W1645397737 hasConcept C159654299 @default.
- W1645397737 hasConcept C163764329 @default.
- W1645397737 hasConcept C185592680 @default.
- W1645397737 hasConcept C203014093 @default.
- W1645397737 hasConcept C2777774473 @default.
- W1645397737 hasConcept C2780420688 @default.
- W1645397737 hasConcept C31258907 @default.
- W1645397737 hasConcept C32022120 @default.
- W1645397737 hasConcept C40875361 @default.
- W1645397737 hasConcept C41008148 @default.
- W1645397737 hasConcept C43617362 @default.
- W1645397737 hasConcept C71924100 @default.
- W1645397737 hasConcept C96618451 @default.
- W1645397737 hasConcept C97355855 @default.
- W1645397737 hasConceptScore W1645397737C10390740 @default.
- W1645397737 hasConceptScore W1645397737C121332964 @default.
- W1645397737 hasConceptScore W1645397737C127162648 @default.
- W1645397737 hasConceptScore W1645397737C147789679 @default.
- W1645397737 hasConceptScore W1645397737C159654299 @default.
- W1645397737 hasConceptScore W1645397737C163764329 @default.
- W1645397737 hasConceptScore W1645397737C185592680 @default.
- W1645397737 hasConceptScore W1645397737C203014093 @default.
- W1645397737 hasConceptScore W1645397737C2777774473 @default.
- W1645397737 hasConceptScore W1645397737C2780420688 @default.
- W1645397737 hasConceptScore W1645397737C31258907 @default.
- W1645397737 hasConceptScore W1645397737C32022120 @default.
- W1645397737 hasConceptScore W1645397737C40875361 @default.
- W1645397737 hasConceptScore W1645397737C41008148 @default.
- W1645397737 hasConceptScore W1645397737C43617362 @default.
- W1645397737 hasConceptScore W1645397737C71924100 @default.
- W1645397737 hasConceptScore W1645397737C96618451 @default.
- W1645397737 hasConceptScore W1645397737C97355855 @default.
- W1645397737 hasLocation W16453977371 @default.
- W1645397737 hasOpenAccess W1645397737 @default.
- W1645397737 hasPrimaryLocation W16453977371 @default.
- W1645397737 hasRelatedWork W2479838848 @default.
- W1645397737 hasRelatedWork W2988549849 @default.
- W1645397737 hasRelatedWork W48222609 @default.
- W1645397737 isParatext "false" @default.
- W1645397737 isRetracted "false" @default.
- W1645397737 magId "1645397737" @default.
- W1645397737 workType "article" @default.