FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1645492839> ?p ?o ?g. }

• W1645492839 endingPage "5053" @default.
• W1645492839 startingPage "5043" @default.
• W1645492839 abstract "Blocked and methylated 5' termini of reovirus mRNA are formed by viral cores at an early stage of transcription. Cores incubated in a complete transcription reaction mixture for 30 s, or in a mixture lacking UTP and ATP for a longer time, synthesize the cap structure, m7GpppGmpC. The dinucleotide ppGpC functions as substrate for a core-associated guanylyltransferase and is converted to GpppGpC by addition of pG from GTP. For optimal conversion, both the diphosphate terminus and phosphodiester bond are required. pGpC is not a substrate, but pppGpC is utilized after removal of the gamma-phosphate by a core nucleotide phospohydrolase. Methyltransferases also present in cores transfer methyl groups sequentially from S-adenosylmethionine (AdoMet) to the N7-position of the 5'-terminal guanosine followed by the 2'-OH of the penultimate guanosine. GpppGpC is hydrolyzed by cores in the presence of pyrophosphate to ppGpC, the predominant 5'-terminal structure of reovirus mRNA made in the absence of S-adenosylmethionine. N7-methylation prevents pyrophosphorolysis of m7GpppGpC, which may explain the increased proportion of blocked, methylated 5' termini in viral mRNA synthesized in the presence of S-adenosylmethionine. On the basis of these findings, the following reaction series is proposed for the synthesis of reovirus mRNA caps. In the series, AdoHcy is the abbreviation for S-adenosylhomocysteine (see article)9" @default.
• W1645492839 created "2016-06-24" @default.
• W1645492839 creator A5000544104 @default.
• W1645492839 creator A5000956824 @default.
• W1645492839 creator A5040854145 @default.
• W1645492839 creator A5080737193 @default.
• W1645492839 date "1976-08-01" @default.
• W1645492839 modified "2023-09-26" @default.
• W1645492839 title "Mechanism of formation of reovirus mRNA 5'-terminal blocked and methylated sequence, m7GpppGmpC." @default.
• W1645492839 cites W1500484927 @default.
• W1645492839 cites W1558315503 @default.
• W1645492839 cites W1565097993 @default.
• W1645492839 cites W1642701560 @default.
• W1645492839 cites W1798250009 @default.
• W1645492839 cites W1895187084 @default.
• W1645492839 cites W1912408357 @default.
• W1645492839 cites W1964111717 @default.
• W1645492839 cites W1969542352 @default.
• W1645492839 cites W1974924927 @default.
• W1645492839 cites W1975751316 @default.
• W1645492839 cites W1976699296 @default.
• W1645492839 cites W1976766465 @default.
• W1645492839 cites W1977291868 @default.
• W1645492839 cites W1978100094 @default.
• W1645492839 cites W1979969348 @default.
• W1645492839 cites W1986232146 @default.
• W1645492839 cites W1987655247 @default.
• W1645492839 cites W1993026672 @default.
• W1645492839 cites W1995107574 @default.
• W1645492839 cites W1998225437 @default.
• W1645492839 cites W2012325540 @default.
• W1645492839 cites W2012326758 @default.
• W1645492839 cites W2016177518 @default.
• W1645492839 cites W2030260846 @default.
• W1645492839 cites W2031577964 @default.
• W1645492839 cites W2031757923 @default.
• W1645492839 cites W2032003548 @default.
• W1645492839 cites W2033115718 @default.
• W1645492839 cites W2040069632 @default.
• W1645492839 cites W2040795551 @default.
• W1645492839 cites W2047785696 @default.
• W1645492839 cites W2050640116 @default.
• W1645492839 cites W2058735050 @default.
• W1645492839 cites W2058870716 @default.
• W1645492839 cites W2058906880 @default.
• W1645492839 cites W2062655901 @default.
• W1645492839 cites W2066705273 @default.
• W1645492839 cites W2070469949 @default.
• W1645492839 cites W2071207834 @default.
• W1645492839 cites W2073621288 @default.
• W1645492839 cites W2077936726 @default.
• W1645492839 cites W2077939569 @default.
• W1645492839 cites W2089266829 @default.
• W1645492839 cites W2091436625 @default.
• W1645492839 cites W2091717941 @default.
• W1645492839 cites W2093838158 @default.
• W1645492839 cites W2119809007 @default.
• W1645492839 cites W2166239756 @default.
• W1645492839 cites W4247647064 @default.
• W1645492839 cites W4249104879 @default.
• W1645492839 doi "https://doi.org/10.1016/s0021-9258(17)33218-0" @default.
• W1645492839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/821947" @default.
• W1645492839 hasPublicationYear "1976" @default.
• W1645492839 type Work @default.
• W1645492839 sameAs 1645492839 @default.
• W1645492839 citedByCount "173" @default.
• W1645492839 countsByYear W16454928392012 @default.
• W1645492839 countsByYear W16454928392013 @default.
• W1645492839 countsByYear W16454928392014 @default.
• W1645492839 countsByYear W16454928392015 @default.
• W1645492839 countsByYear W16454928392016 @default.
• W1645492839 countsByYear W16454928392017 @default.
• W1645492839 countsByYear W16454928392018 @default.
• W1645492839 countsByYear W16454928392019 @default.
• W1645492839 countsByYear W16454928392020 @default.
• W1645492839 countsByYear W16454928392021 @default.
• W1645492839 countsByYear W16454928392022 @default.
• W1645492839 countsByYear W16454928392023 @default.
• W1645492839 crossrefType "journal-article" @default.
• W1645492839 hasAuthorship W1645492839A5000544104 @default.
• W1645492839 hasAuthorship W1645492839A5000956824 @default.
• W1645492839 hasAuthorship W1645492839A5040854145 @default.
• W1645492839 hasAuthorship W1645492839A5080737193 @default.
• W1645492839 hasBestOaLocation W16454928391 @default.
• W1645492839 hasConcept C104317684 @default.
• W1645492839 hasConcept C105580179 @default.
• W1645492839 hasConcept C121332964 @default.
• W1645492839 hasConcept C153911025 @default.
• W1645492839 hasConcept C185592680 @default.
• W1645492839 hasConcept C2778112365 @default.
• W1645492839 hasConcept C2779664074 @default.
• W1645492839 hasConcept C31258907 @default.
• W1645492839 hasConcept C41008148 @default.
• W1645492839 hasConcept C55493867 @default.
• W1645492839 hasConcept C62520636 @default.
• W1645492839 hasConcept C86803240 @default.
• W1645492839 hasConcept C89611455 @default.
• W1645492839 hasConcept C95444343 @default.

• next