FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1645705593> ?p ?o ?g. }

• W1645705593 endingPage "213" @default.
• W1645705593 startingPage "202" @default.
• W1645705593 abstract "Brain development goes through phases of proliferative growth and differentiation to ensure the formation of correct number and variety of neurons. How and when naïve neuroepithelial cells decide to enter a differentiation pathway remains poorly understood. In the Drosophila visual system, four optic ganglia emerge from neuroepithelia of the inner (IPC) and outer (OPC) proliferation centers. Here we demonstrate that the orphan nuclear receptor Tailless (Tll) is a key factor for the development of all optic ganglia. We describe tll expression during larval optic lobe development in unprecedented detail and find a spatiotemporally dynamic pattern. In the larval OPC, symmetrically dividing neuroepithelial cells transform into asymmetrically dividing medulla neuroblast and into lamina precursor cells in a precisely regulated fashion. Using genetic manipulations we found that tll is required for proper neuroepithelium morphology and neuroepithelial cell survival. We show that tll regulates the precise timing of the transition from neuroepithelial cells to medulla neuroblasts. In particular, however, we demonstrate that tll has a crucial role for the specification of lamina precursor cells. We propose that the Tll/Tlx transcription factors have an evolutionary conserved role in regulating neural precursor cell states in the Drosophila optic lobe and in the mammalian retina." @default.
• W1645705593 created "2016-06-24" @default.
• W1645705593 creator A5024637580 @default.
• W1645705593 creator A5032725766 @default.
• W1645705593 creator A5043406126 @default.
• W1645705593 creator A5071362153 @default.
• W1645705593 date "2015-09-01" @default.
• W1645705593 modified "2023-09-24" @default.
• W1645705593 title "Characterization of tailless functions during Drosophila optic lobe formation" @default.
• W1645705593 cites W1848130254 @default.
• W1645705593 cites W1974501985 @default.
• W1645705593 cites W1978648122 @default.
• W1645705593 cites W1979046532 @default.
• W1645705593 cites W1989575185 @default.
• W1645705593 cites W1990260908 @default.
• W1645705593 cites W1993182457 @default.
• W1645705593 cites W1993445706 @default.
• W1645705593 cites W2003624323 @default.
• W1645705593 cites W2009463608 @default.
• W1645705593 cites W2011405275 @default.
• W1645705593 cites W2014532007 @default.
• W1645705593 cites W2017059359 @default.
• W1645705593 cites W2017439745 @default.
• W1645705593 cites W2026833123 @default.
• W1645705593 cites W2030573242 @default.
• W1645705593 cites W2036605543 @default.
• W1645705593 cites W2048089231 @default.
• W1645705593 cites W2077905736 @default.
• W1645705593 cites W2080570840 @default.
• W1645705593 cites W2098003895 @default.
• W1645705593 cites W2111105486 @default.
• W1645705593 cites W2111121145 @default.
• W1645705593 cites W2122502711 @default.
• W1645705593 cites W2123787611 @default.
• W1645705593 cites W2130357489 @default.
• W1645705593 cites W2139452105 @default.
• W1645705593 cites W2139587743 @default.
• W1645705593 cites W2144267063 @default.
• W1645705593 cites W2145621796 @default.
• W1645705593 cites W2156130127 @default.
• W1645705593 cites W2159817218 @default.
• W1645705593 cites W2165861450 @default.
• W1645705593 cites W2186418116 @default.
• W1645705593 cites W2331195544 @default.
• W1645705593 cites W2409971213 @default.
• W1645705593 cites W2994972371 @default.
• W1645705593 cites W4210339143 @default.
• W1645705593 doi "https://doi.org/10.1016/j.ydbio.2015.06.011" @default.
• W1645705593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26111972" @default.
• W1645705593 hasPublicationYear "2015" @default.
• W1645705593 type Work @default.
• W1645705593 sameAs 1645705593 @default.
• W1645705593 citedByCount "13" @default.
• W1645705593 countsByYear W16457055932015 @default.
• W1645705593 countsByYear W16457055932016 @default.
• W1645705593 countsByYear W16457055932017 @default.
• W1645705593 countsByYear W16457055932020 @default.
• W1645705593 countsByYear W16457055932021 @default.
• W1645705593 countsByYear W16457055932022 @default.
• W1645705593 crossrefType "journal-article" @default.
• W1645705593 hasAuthorship W1645705593A5024637580 @default.
• W1645705593 hasAuthorship W1645705593A5032725766 @default.
• W1645705593 hasAuthorship W1645705593A5043406126 @default.
• W1645705593 hasAuthorship W1645705593A5071362153 @default.
• W1645705593 hasBestOaLocation W16457055932 @default.
• W1645705593 hasConcept C105702510 @default.
• W1645705593 hasConcept C124964019 @default.
• W1645705593 hasConcept C136834591 @default.
• W1645705593 hasConcept C1491633281 @default.
• W1645705593 hasConcept C169760540 @default.
• W1645705593 hasConcept C17291353 @default.
• W1645705593 hasConcept C200707615 @default.
• W1645705593 hasConcept C2777093970 @default.
• W1645705593 hasConcept C28328180 @default.
• W1645705593 hasConcept C39961270 @default.
• W1645705593 hasConcept C4746552 @default.
• W1645705593 hasConcept C54355233 @default.
• W1645705593 hasConcept C86803240 @default.
• W1645705593 hasConcept C95444343 @default.
• W1645705593 hasConceptScore W1645705593C105702510 @default.
• W1645705593 hasConceptScore W1645705593C124964019 @default.
• W1645705593 hasConceptScore W1645705593C136834591 @default.
• W1645705593 hasConceptScore W1645705593C1491633281 @default.
• W1645705593 hasConceptScore W1645705593C169760540 @default.
• W1645705593 hasConceptScore W1645705593C17291353 @default.
• W1645705593 hasConceptScore W1645705593C200707615 @default.
• W1645705593 hasConceptScore W1645705593C2777093970 @default.
• W1645705593 hasConceptScore W1645705593C28328180 @default.
• W1645705593 hasConceptScore W1645705593C39961270 @default.
• W1645705593 hasConceptScore W1645705593C4746552 @default.
• W1645705593 hasConceptScore W1645705593C54355233 @default.
• W1645705593 hasConceptScore W1645705593C86803240 @default.
• W1645705593 hasConceptScore W1645705593C95444343 @default.
• W1645705593 hasIssue "2" @default.
• W1645705593 hasLocation W16457055931 @default.
• W1645705593 hasLocation W16457055932 @default.
• W1645705593 hasLocation W16457055933 @default.
• W1645705593 hasLocation W16457055934 @default.

• next