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- W1645709893 abstract "Summary Hexokinase isozymes in rat tissues were electrophoretically separated on cellulose acetate membrane. The method was very quick and gave reproducible results. By using this method, hexokinase isozyme patterns were studied on normal rat liver and experimental hepatomas with differing growth rates and degrees of differentiation. In normal rat liver, the hexokinase pattern obtained on cellulose acetate membrane was identical with that obtained on starch gel by previous workers. There were four types of hexokinases, which corresponded to Types I, II, III, and IV hexokinases according to Katzen and Schimke, in order of increasing mobility from the origin to the anode. Type IV hexokinase, which was stained most intensely, was glucokinase, and duplication of Type IV hexokinase into two bands (IV s , slow form, and IV f , fast form) was occasionally observed. Morris hepatomas, as a slowly growing and less deviated hepatoma group, showed relatively predominant Type II hexokinase in addition to Types I and III hexokinases, and they also had a faint Type IV hexokinase band. A rapidly growing and highly deviated hepatoma group, Yoshida ascitcs hepatomas were characterized by the presence of only Type I hexokinase and marked Type II hexokinase and by the loss of Type IV and Type III hexokinases. Yoshida sarcoma showed a similar hexokinase pattern to that of Yoshida ascites hepatomas. A slowly growing substrain of Yoshida sarcoma, LY 5, had also Type III and Type IV hexokinases, resembling Morris hepatomas. These observations suggested that the genes for Types III and IV hexokinase isozymes were not deleted, but their expressions were blocked in the original Yoshida sarcoma. The regenerating liver was analogous to Morris hepatomas in hexokinase pattern. In fetal liver, Type II hexokinase was dominant, in addition to Types I, III, and weak IV hexokinases." @default.
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- W1645709893 date "1969-07-01" @default.
- W1645709893 modified "2023-09-29" @default.
- W1645709893 title "Hexokinase isozyme patterns of experimental hepatomas of rats." @default.
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