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• W1645795322 endingPage "654" @default.
• W1645795322 startingPage "647" @default.
• W1645795322 abstract "Abstract The protein kinase C (PKC) family of intracellular enzymes plays a crucial role in signal transduction for a variety of cellular responses of mononuclear phagocytes including phagocytosis, oxidative burst, and secretion. Alterations in the activation pathways of PKC in a variety of cell types have been implicated in the pathogenesis of the complications of diabetes. In this study, we investigated the consequences of PKC activation by evaluating endogenous phosphorylation of PKC substrates with a phosphospecific PKC substrate Ab (pPKC(s)). Phosphorylation of a 40-kDa protein was significantly increased in mononuclear phagocytes from diabetics. Phosphorylation of this protein is downstream of PKC activation and its phosphorylated form was found to be associated with the membrane. Mass spectrometry analysis, immunoprecipitation, and immunoblotting experiments revealed that this 40-kDa protein is pleckstrin. We then investigated the phosphorylation and translocation of pleckstrin in response to the activation of receptor for advanced glycation end products (RAGE). The results suggest that pleckstrin is involved in RAGE signaling and advanced glycation end product (AGE)-elicited mononuclear phagocyte dysfunction. Suppression of pleckstrin expression with RNA interference silencing revealed that phosphorylation of pleckstrin is an important intermediate in the secretion and activation pathways of proinflammatory cytokines (TNF-α and IL-1β) induced by RAGE activation. In summary, this study demonstrates that phosphorylation of pleckstrin is up-regulated in diabetic mononuclear phagocytes. The phosphorylation is in part due to the activation of PKC through RAGE binding, and pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated AGE in diabetes." @default.
• W1645795322 created "2016-06-24" @default.
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• W1645795322 creator A5055616548 @default.
• W1645795322 creator A5061879506 @default.
• W1645795322 date "2007-07-01" @default.
• W1645795322 modified "2023-09-27" @default.
• W1645795322 title "Phosphorylation of Pleckstrin Increases Proinflammatory Cytokine Secretion by Mononuclear Phagocytes in Diabetes Mellitus" @default.
• W1645795322 cites W10026949 @default.
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• W1645795322 cites W1534164957 @default.
• W1645795322 cites W1576671418 @default.
• W1645795322 cites W1579720892 @default.
• W1645795322 cites W1838703570 @default.
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• W1645795322 cites W1987796811 @default.
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• W1645795322 cites W1994422962 @default.
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• W1645795322 doi "https://doi.org/10.4049/jimmunol.179.1.647" @default.
• W1645795322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2150995" @default.
• W1645795322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17579087" @default.
• W1645795322 hasPublicationYear "2007" @default.
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