Matches in SemOpenAlex for { <https://semopenalex.org/work/W1645800103> ?p ?o ?g. }
- W1645800103 endingPage "117" @default.
- W1645800103 startingPage "95" @default.
- W1645800103 abstract "Publisher Summary This chapter describes the epigenetic targets in γ‐aminobutyric acid (GABAergic) neurons to treat schizophrenia (SZ). In the cortical GABAergic neurons of SZ patients, transcriptional downregulation of genes, encoding several proteins critical for neuronal plasticity, such as reelin and GAD 67 , is related to an epigenetic hypermethylation of their corresponding promoters by DNA methyltransferase 1 (DNMT1), which is selectively overexpressed in these neurons. Epigenetic changes in the regulation of reelin and GAD 67 contribute to the sculpting of specific neuroanatomical, neurochemical, and behavioral endophenotypes in SZ. These changes can be treated by targeting the aberrations in epigenetic function detected in the cortical GABAergic neurons of SZ patients. A multicenter double‐blind study shows that atypical antipsychotics have a faster onset of response when combined with valproic acid (VPA). VPA is a histone deacetylase (HDAC) inhibitor that suggests that supplementation of atypical anti-psychotics with HDAC inhibitors elicits a faster onset of specific epigenetic transcriptional changes underlying antipsychotic efficacy. The findings discussed in the chapter offer new opportunities for “epigenetic treatments” aimed at decreasing the hypermethylation of promoters that are associated with GABAergic dysfunction in SZ." @default.
- W1645800103 created "2016-06-24" @default.
- W1645800103 creator A5026126010 @default.
- W1645800103 creator A5039884481 @default.
- W1645800103 creator A5048825104 @default.
- W1645800103 creator A5051515082 @default.
- W1645800103 creator A5075306037 @default.
- W1645800103 creator A5083924174 @default.
- W1645800103 creator A5091526893 @default.
- W1645800103 date "2006-01-01" @default.
- W1645800103 modified "2023-09-23" @default.
- W1645800103 title "Epigenetic Targets in GABAergic Neurons to Treat Schizophrenia" @default.
- W1645800103 cites W1492557229 @default.
- W1645800103 cites W1523349613 @default.
- W1645800103 cites W1554656840 @default.
- W1645800103 cites W1598713761 @default.
- W1645800103 cites W1656220430 @default.
- W1645800103 cites W1660095449 @default.
- W1645800103 cites W1667992367 @default.
- W1645800103 cites W1964486755 @default.
- W1645800103 cites W1965123277 @default.
- W1645800103 cites W1967321689 @default.
- W1645800103 cites W1967982538 @default.
- W1645800103 cites W1970393142 @default.
- W1645800103 cites W1971334707 @default.
- W1645800103 cites W1973161736 @default.
- W1645800103 cites W1974021095 @default.
- W1645800103 cites W1974849634 @default.
- W1645800103 cites W1979219206 @default.
- W1645800103 cites W1979890518 @default.
- W1645800103 cites W1985675810 @default.
- W1645800103 cites W1985731915 @default.
- W1645800103 cites W1989700831 @default.
- W1645800103 cites W1992811119 @default.
- W1645800103 cites W1993423079 @default.
- W1645800103 cites W2001688761 @default.
- W1645800103 cites W2004172747 @default.
- W1645800103 cites W2005044038 @default.
- W1645800103 cites W2006154315 @default.
- W1645800103 cites W2008201324 @default.
- W1645800103 cites W2009680012 @default.
- W1645800103 cites W2010629311 @default.
- W1645800103 cites W2020699105 @default.
- W1645800103 cites W2023441280 @default.
- W1645800103 cites W2023797597 @default.
- W1645800103 cites W2025801062 @default.
- W1645800103 cites W2026696795 @default.
- W1645800103 cites W2041241261 @default.
- W1645800103 cites W2046244011 @default.
- W1645800103 cites W2046459630 @default.
- W1645800103 cites W2052842503 @default.
- W1645800103 cites W2053256857 @default.
- W1645800103 cites W2053919363 @default.
- W1645800103 cites W2054017008 @default.
- W1645800103 cites W2059097951 @default.
- W1645800103 cites W2064429646 @default.
- W1645800103 cites W2068222511 @default.
- W1645800103 cites W2068564214 @default.
- W1645800103 cites W2070312499 @default.
- W1645800103 cites W2072551779 @default.
- W1645800103 cites W2074489888 @default.
- W1645800103 cites W2077844146 @default.
- W1645800103 cites W2079396188 @default.
- W1645800103 cites W2080843993 @default.
- W1645800103 cites W2089912569 @default.
- W1645800103 cites W2095605218 @default.
- W1645800103 cites W2098955633 @default.
- W1645800103 cites W2103405252 @default.
- W1645800103 cites W2107733280 @default.
- W1645800103 cites W2109640950 @default.
- W1645800103 cites W2112828663 @default.
- W1645800103 cites W2117879536 @default.
- W1645800103 cites W2118059649 @default.
- W1645800103 cites W2120492811 @default.
- W1645800103 cites W2124538861 @default.
- W1645800103 cites W2144291844 @default.
- W1645800103 cites W2146070554 @default.
- W1645800103 cites W2146702633 @default.
- W1645800103 cites W2153228112 @default.
- W1645800103 cites W2155924534 @default.
- W1645800103 cites W2156305088 @default.
- W1645800103 cites W2162660143 @default.
- W1645800103 cites W2163154029 @default.
- W1645800103 cites W2168942809 @default.
- W1645800103 cites W2170286329 @default.
- W1645800103 cites W2171559879 @default.
- W1645800103 cites W2952410637 @default.
- W1645800103 cites W4238550549 @default.
- W1645800103 cites W4251401827 @default.
- W1645800103 doi "https://doi.org/10.1016/s1054-3589(06)54005-0" @default.
- W1645800103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17175812" @default.
- W1645800103 hasPublicationYear "2006" @default.
- W1645800103 type Work @default.
- W1645800103 sameAs 1645800103 @default.
- W1645800103 citedByCount "25" @default.
- W1645800103 countsByYear W16458001032012 @default.
- W1645800103 countsByYear W16458001032013 @default.
- W1645800103 countsByYear W16458001032014 @default.