Matches in SemOpenAlex for { <https://semopenalex.org/work/W16458591> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W16458591 endingPage "3" @default.
- W16458591 startingPage "100" @default.
- W16458591 abstract "Erythrocyte (ENH3) and plasma (PNH3) ammonia levels, liver function tests and plasma valproate concentration were measured in 81 epileptic patients, comprising three therapeutic groups: Group 1 (23 patients) received sodium valproate (VPA) monotherapy, group 2 (33 patients) received sodium valproate combined with phenytoin, carbamazepine, phenobarbitone and/or primidone and group 3 (25 patients) received one or more of these anti-epileptic drugs without sodium valproate. The mean ENH3 and PNH3 of patients in group 1 (41.1 +/- 30.7 mumol l-1 and 37.1 +/- 31.8 mumol l-1, respectively) and group 2 (44.5 +/- 21.3 and 37.6 +/- 21.4 mumol l-1, respectively) were significantly (P less than 0.01) higher than those in group 3 (28.7 +/- 10.6 and 21.5 +/- 7.8 mumol l-1, respectively) and the reference range (30.1 +/- 7.9 and 20.8 +/- 5.7 mumol l-1, respectively). Hyperammonaemia was more prevalent amongst patients in group 2, for both ENH3 (45.5%) and PNH3 (54.6%), than amongst patients in group 1 (30.4% and 52.2%, respectively) and group 3 (8% and 8%, respectively). There was a significant (P less than 0.05) positive correlation between plasma VPA and total bilirubin concentrations. Chronic VPA therapy was also associated with an increase in bilirubin concentrations measured on average four months apart." @default.
- W16458591 created "2016-06-24" @default.
- W16458591 creator A5002514412 @default.
- W16458591 creator A5004737613 @default.
- W16458591 creator A5012605654 @default.
- W16458591 creator A5033831548 @default.
- W16458591 creator A5057183741 @default.
- W16458591 date "1986-07-01" @default.
- W16458591 modified "2023-09-23" @default.
- W16458591 title "Hyperammonaemia and hepatotoxicity during chronic valproate therapy: enhancement by combination with other antiepileptic drugs." @default.
- W16458591 cites W1996183096 @default.
- W16458591 cites W2005593733 @default.
- W16458591 cites W2012443908 @default.
- W16458591 cites W2019824692 @default.
- W16458591 cites W2035056756 @default.
- W16458591 cites W2044305504 @default.
- W16458591 cites W2058706203 @default.
- W16458591 cites W2065812649 @default.
- W16458591 cites W2077094466 @default.
- W16458591 cites W2111826761 @default.
- W16458591 cites W2118375664 @default.
- W16458591 cites W2189563903 @default.
- W16458591 cites W2269253680 @default.
- W16458591 cites W70018333 @default.
- W16458591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1401093" @default.
- W16458591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3091053" @default.
- W16458591 hasPublicationYear "1986" @default.
- W16458591 type Work @default.
- W16458591 sameAs 16458591 @default.
- W16458591 citedByCount "11" @default.
- W16458591 countsByYear W164585912022 @default.
- W16458591 crossrefType "journal-article" @default.
- W16458591 hasAuthorship W16458591A5002514412 @default.
- W16458591 hasAuthorship W16458591A5004737613 @default.
- W16458591 hasAuthorship W16458591A5012605654 @default.
- W16458591 hasAuthorship W16458591A5033831548 @default.
- W16458591 hasAuthorship W16458591A5057183741 @default.
- W16458591 hasConcept C118552586 @default.
- W16458591 hasConcept C126322002 @default.
- W16458591 hasConcept C178790620 @default.
- W16458591 hasConcept C185592680 @default.
- W16458591 hasConcept C2775858608 @default.
- W16458591 hasConcept C2777172819 @default.
- W16458591 hasConcept C2777513400 @default.
- W16458591 hasConcept C2777992146 @default.
- W16458591 hasConcept C2778186239 @default.
- W16458591 hasConcept C2778337148 @default.
- W16458591 hasConcept C2778793413 @default.
- W16458591 hasConcept C2779253243 @default.
- W16458591 hasConcept C2992208098 @default.
- W16458591 hasConcept C537181965 @default.
- W16458591 hasConcept C71924100 @default.
- W16458591 hasConcept C90924648 @default.
- W16458591 hasConcept C98274493 @default.
- W16458591 hasConceptScore W16458591C118552586 @default.
- W16458591 hasConceptScore W16458591C126322002 @default.
- W16458591 hasConceptScore W16458591C178790620 @default.
- W16458591 hasConceptScore W16458591C185592680 @default.
- W16458591 hasConceptScore W16458591C2775858608 @default.
- W16458591 hasConceptScore W16458591C2777172819 @default.
- W16458591 hasConceptScore W16458591C2777513400 @default.
- W16458591 hasConceptScore W16458591C2777992146 @default.
- W16458591 hasConceptScore W16458591C2778186239 @default.
- W16458591 hasConceptScore W16458591C2778337148 @default.
- W16458591 hasConceptScore W16458591C2778793413 @default.
- W16458591 hasConceptScore W16458591C2779253243 @default.
- W16458591 hasConceptScore W16458591C2992208098 @default.
- W16458591 hasConceptScore W16458591C537181965 @default.
- W16458591 hasConceptScore W16458591C71924100 @default.
- W16458591 hasConceptScore W16458591C90924648 @default.
- W16458591 hasConceptScore W16458591C98274493 @default.
- W16458591 hasIssue "1" @default.
- W16458591 hasLocation W164585911 @default.
- W16458591 hasOpenAccess W16458591 @default.
- W16458591 hasPrimaryLocation W164585911 @default.
- W16458591 hasRelatedWork W16458591 @default.
- W16458591 hasRelatedWork W1971954813 @default.
- W16458591 hasRelatedWork W2051876872 @default.
- W16458591 hasRelatedWork W2087744633 @default.
- W16458591 hasRelatedWork W2088315540 @default.
- W16458591 hasRelatedWork W2090236621 @default.
- W16458591 hasRelatedWork W2107356373 @default.
- W16458591 hasRelatedWork W2142371498 @default.
- W16458591 hasRelatedWork W2396026399 @default.
- W16458591 hasRelatedWork W2398413044 @default.
- W16458591 hasVolume "22" @default.
- W16458591 isParatext "false" @default.
- W16458591 isRetracted "false" @default.
- W16458591 magId "16458591" @default.
- W16458591 workType "article" @default.