FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1645900857> ?p ?o ?g. }

• W1645900857 endingPage "50" @default.
• W1645900857 startingPage "43" @default.
• W1645900857 abstract "The kaolin-mediated reciprocal activation of bovine factor XII and prekallikrein was divided into the following two reactions: the activation of factor XII by plasma kallikrein (reaction 1) and the activation of prekallikrein by factor XIIa (reaction 2). The effects of high-Mr kininogen and kalin surface on the kinetics of these activation reactions were studied. High-Mr kininogen markedly enhanced the rate of reactions 1 and 2 in the presence of kaolin, and the enhancements were highly dependent on the concentrations of the protein cofactor and amount of kaolin surface. For the activation of factor XII by plasma kallikrein (reaction 1), high-Mr kininogen was required when a low concentration of factor XII and kaolin was used. The molar ratio of the protein cofactor to factor XII for optimal activation was found to be approximately 1:1. The apparent Km value and the kcat/Km value for plasma kallikrein on factor XII were calculated to be 4 nM and 5.2 − 107 s−1· M−1, respectively. The activation of prekallikrein by factor XIIa, (reaction 2) proceeded even in the absence of high-Mr kininogen and kaolin. The addition of the protein cofactor and surface to the reaction mixture remarkably accelerated the reaction, and the apparent Km value for factor XIIa on prekallikrein was reduced from 1 μM to 40 nM. Moreover, the kcat/Km value was altered from 7.3 − 104 to 1.1 − 106 s−1· M−1. These results suggest that high-Mr kininogen accelerates the surface-mediated activation of factor XII and prekallikrein by enhancing the susceptibility of factor XII to plasma kallikrein, on the one hand, and the affinity of factor XIIa for prekallikrein, on the other hand. Kaolin may play an important role in the concentration and organization of these components on the negatively charged surface." @default.
• W1645900857 created "2016-06-24" @default.
• W1645900857 creator A5014673096 @default.
• W1645900857 creator A5030280330 @default.
• W1645900857 creator A5038813552 @default.
• W1645900857 creator A5053289422 @default.
• W1645900857 creator A5072051494 @default.
• W1645900857 date "1985-01-01" @default.
• W1645900857 modified "2023-10-14" @default.
• W1645900857 title "Kinetic studies on surface-mediated activation of bovine factor XII and prekallikrein. Effects of kaolin and high-Mr kininogen on the activation reactions" @default.
• W1645900857 cites W1484115349 @default.
• W1645900857 cites W1488573465 @default.
• W1645900857 cites W1526356170 @default.
• W1645900857 cites W1557125148 @default.
• W1645900857 cites W1575067834 @default.
• W1645900857 cites W1605867408 @default.
• W1645900857 cites W1907990126 @default.
• W1645900857 cites W191871818 @default.
• W1645900857 cites W1967508759 @default.
• W1645900857 cites W1970772713 @default.
• W1645900857 cites W1971163929 @default.
• W1645900857 cites W1976257261 @default.
• W1645900857 cites W1976444346 @default.
• W1645900857 cites W1985469117 @default.
• W1645900857 cites W1996282461 @default.
• W1645900857 cites W2040720753 @default.
• W1645900857 cites W2041911603 @default.
• W1645900857 cites W2055393770 @default.
• W1645900857 cites W2055667942 @default.
• W1645900857 cites W2059975829 @default.
• W1645900857 cites W2067723178 @default.
• W1645900857 cites W2069612260 @default.
• W1645900857 cites W2078200855 @default.
• W1645900857 cites W2092462079 @default.
• W1645900857 cites W2098979350 @default.
• W1645900857 cites W2103498254 @default.
• W1645900857 cites W2106158854 @default.
• W1645900857 cites W2117413916 @default.
• W1645900857 cites W2157488373 @default.
• W1645900857 cites W2467467260 @default.
• W1645900857 cites W613768291 @default.
• W1645900857 cites W928200883 @default.
• W1645900857 doi "https://doi.org/10.1111/j.1432-1033.1985.tb08617.x" @default.
• W1645900857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3871394" @default.
• W1645900857 hasPublicationYear "1985" @default.
• W1645900857 type Work @default.
• W1645900857 sameAs 1645900857 @default.
• W1645900857 citedByCount "29" @default.
• W1645900857 countsByYear W16459008572012 @default.
• W1645900857 countsByYear W16459008572014 @default.
• W1645900857 countsByYear W16459008572016 @default.
• W1645900857 countsByYear W16459008572018 @default.
• W1645900857 countsByYear W16459008572019 @default.
• W1645900857 countsByYear W16459008572021 @default.
• W1645900857 crossrefType "journal-article" @default.
• W1645900857 hasAuthorship W1645900857A5014673096 @default.
• W1645900857 hasAuthorship W1645900857A5030280330 @default.
• W1645900857 hasAuthorship W1645900857A5038813552 @default.
• W1645900857 hasAuthorship W1645900857A5053289422 @default.
• W1645900857 hasAuthorship W1645900857A5072051494 @default.
• W1645900857 hasBestOaLocation W16459008571 @default.
• W1645900857 hasConcept C126322002 @default.
• W1645900857 hasConcept C152328610 @default.
• W1645900857 hasConcept C181199279 @default.
• W1645900857 hasConcept C185592680 @default.
• W1645900857 hasConcept C2777167447 @default.
• W1645900857 hasConcept C2777902427 @default.
• W1645900857 hasConcept C2778382381 @default.
• W1645900857 hasConcept C2781317560 @default.
• W1645900857 hasConcept C52853521 @default.
• W1645900857 hasConcept C55493867 @default.
• W1645900857 hasConcept C71924100 @default.
• W1645900857 hasConceptScore W1645900857C126322002 @default.
• W1645900857 hasConceptScore W1645900857C152328610 @default.
• W1645900857 hasConceptScore W1645900857C181199279 @default.
• W1645900857 hasConceptScore W1645900857C185592680 @default.
• W1645900857 hasConceptScore W1645900857C2777167447 @default.
• W1645900857 hasConceptScore W1645900857C2777902427 @default.
• W1645900857 hasConceptScore W1645900857C2778382381 @default.
• W1645900857 hasConceptScore W1645900857C2781317560 @default.
• W1645900857 hasConceptScore W1645900857C52853521 @default.
• W1645900857 hasConceptScore W1645900857C55493867 @default.
• W1645900857 hasConceptScore W1645900857C71924100 @default.
• W1645900857 hasIssue "1" @default.
• W1645900857 hasLocation W16459008571 @default.
• W1645900857 hasLocation W16459008572 @default.
• W1645900857 hasOpenAccess W1645900857 @default.
• W1645900857 hasPrimaryLocation W16459008571 @default.
• W1645900857 hasRelatedWork W1888682425 @default.
• W1645900857 hasRelatedWork W1982170684 @default.
• W1645900857 hasRelatedWork W1990266683 @default.
• W1645900857 hasRelatedWork W1996282461 @default.
• W1645900857 hasRelatedWork W2053692752 @default.
• W1645900857 hasRelatedWork W2058162127 @default.
• W1645900857 hasRelatedWork W2087037963 @default.
• W1645900857 hasRelatedWork W2175700465 @default.
• W1645900857 hasRelatedWork W2340244022 @default.
• W1645900857 hasRelatedWork W2968890440 @default.

• next