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- W1645947377 abstract "Investigation of anti-coronavirus-antibodies in the cerebrospinal fluid for the diagnosis of CNS manifestation of feline infectious peritonitisThe purpose of the present study was to evaluate the occurence of anti-coronavirus antibodies in the cerebrospinal fluid (CSF) of cats and to assess their diagnostic utility concerning the central nervous system (CNS) manifestation of feline infectious peritonitis (FIP). Anti-coronavirus immunoglobulin G (IgG) was measured in CSF and serum of 67 cats by indirect immunofluorescence assay. Additionally, cell counts, Pandy’s test and total protein were performed in the CSF. Diagnosis of all cats was confirmed by gross and histological examination including the brain. Four different groups were examined: FIP with CNS manifestation (n = 10), FIP without CNS manifestation (n = 13), other CNS disorders than FIP (n = 29) and diseases not associated with FIP and not involving the CNS (n = 15).Anti-coronavirus IgG was detected in the CSF of 18% of all cats (12/67): 6 cats with FIP involving the CNS, 4 cats with FIP not involving the CNS and 2 cats with brain tumours. CSF antibodies were only found in seropositive cats. In addition, only cats with serum titers equal or higher than 1:4096 showed CSF titers. The correlation between serum antibodies and CSF antibodies was statistically highly significant (r=0,652; p=0,000). No statistically significant correlation was found between the erythrocyte count and CSF titers. However, a certain tendency for high CSF titers with increasing numbers of erythrocytes was observed.For all cats of the study (n = 67), testing for anti-coronavirus IgG in the CSF showed a sensitivity of 60% and a specificity of 90%. CSF antibodies had a positive predictive value of 50% for the CNS manifestation of FIP. The negative predictive value was 93%.Calculating only the values of cats with CNS alterations (n = 39), testing for anti-coronavirus IgG in the CSF had a sensitivity of 60% and a specificity of 93%. The positive and negative predictive value was 75% and 87%, respectively. The present study revealed that the determination of anti-coronavirus-titers in the CSF alone does not confirm CNS manifestation of FIP. The statistically highly significant correlation between CSF and serum antibodies indicates a disrupted blood brain barrier or blood contamination. Future studies on CSF anti-coronavirus-antibodies should address the evaluation of the status of the blood brain barrier and the measurement of the intrathecally produced antibody portion." @default.
- W1645947377 created "2016-06-24" @default.
- W1645947377 creator A5081723679 @default.
- W1645947377 date "2004-07-23" @default.
- W1645947377 modified "2023-09-24" @default.
- W1645947377 title "Untersuchung des Stellenwertes der Messung spezifischer Antikörper im Liquor cerebrospinalis für die Diagnose der ZNS-Manifestation der Felinen Infektiösen Peritonitis" @default.
- W1645947377 hasPublicationYear "2004" @default.
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