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- W1646044251 abstract "textabstractSepsis and its sequelae are the leading cause of mortality in todays medical and surgicalintensive care. The incidence of sepsis continues to increase. Mortality of septic shock rangesfrom 30 to 80% depending on the severity of disease and the presence of organ failure. Despiterecent progress in antibiotic therapy and intensive care support mortality from septic shock hasremained high over the last years. Sepsis can be defmed as the systemic response to severe infection.' When certainmicro-organisms or their toxic products invade the bloodstream, this may result in a widevariety of symptoms that are characteristic of sepsis and its sequelae (Table 1). Whenhypotension develops unresponsive to fluid therapy and signs of inadequate organ perfusionare present, the condition is often referred to as septic shock.s Shock develops inapproximately 40 % of septic patients. The initial cardiovascular changes during hyperdynamicsepsis are characterized by massive vasodilatation with a normal to high cardiac output, lowperipheral vascular resistance and severe hypotension.' In a large number of patients theinitial hypotension is unresponsive to treatment with fluid substitution or vasopressors.Umesponsive hypotension is present in 50% of patients that die of septic shock. In the firstweek unresponsive hypotension is the primary cause of mortality of septic patients. In the laterstages of sepsis, the hyperdynamic circulatory state may turn into hypodynamic septic shockwitl! failure to guarantee adequate oxygen supply to tissues and irreversible organ damage. Ina retrospective study with one hundred intensive care patients with sepsis 80% of mortality inthe first week was caused by severe hypotension." @default.
- W1646044251 created "2016-06-24" @default.
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- W1646044251 date "1998-09-09" @default.
- W1646044251 modified "2023-09-26" @default.
- W1646044251 title "Nitric Oxide in Septic Shock: an experimental and clinical study" @default.
- W1646044251 hasPublicationYear "1998" @default.
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