Matches in SemOpenAlex for { <https://semopenalex.org/work/W1646234539> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1646234539 endingPage "3177" @default.
- W1646234539 startingPage "3173" @default.
- W1646234539 abstract "Although nonsteroidal antiestrogens of the triphenylethylene type are generally considered to act through the estrogen receptor, some observations suggest that estrogen target tissues may also contain a binding protein specific for these compounds. The data so far reported, however, are also consistent with ligand-induced changes in conformation or in the state of aggregation of the estrogen receptor. The studies reported here demonstrate the existence of a protein in human myometrial cytosol which binds 1-[4-(2-dimethylaminoethoxy)phenyl]1,2-diphenylbut-1(Z)-ene ([3H]tamoxifen) with high affinity (Kd = 2.3 X 10(-9) M). This protein exhibits striking specificity for nonsteroidal antiestrogens. Estradiol competes weakly for bound [3H]tamoxifen, while other estrogens and nonestrogenic steroid hormones do not compete at all. Sedimentation analysis and molecular sieve chromatography indicate that the antiestrogen-binding protein is a larger species than the estrogen receptor and elutes from DEAE-Sephacel at a lower KCl concentration (0.03 M) than the estrogen receptor (0.15 M). Differential thermal stability of the estrogen receptor and the antiestrogen-binding protein was demonstrable in the absence of added ligand. The antiestrogen-binding protein was ubiquitous, being present in many tissues where estrogen receptor was undetectable. These findings support the separate existence of an antiestrogen-binding protein." @default.
- W1646234539 created "2016-06-24" @default.
- W1646234539 creator A5032706436 @default.
- W1646234539 date "1983-03-01" @default.
- W1646234539 modified "2023-09-26" @default.
- W1646234539 title "An antiestrogen-binding protein in human tissues." @default.
- W1646234539 cites W1500416364 @default.
- W1646234539 cites W1775749144 @default.
- W1646234539 cites W1906197854 @default.
- W1646234539 cites W1969381687 @default.
- W1646234539 cites W1972404989 @default.
- W1646234539 cites W1981959249 @default.
- W1646234539 cites W1983649348 @default.
- W1646234539 cites W2006812453 @default.
- W1646234539 cites W2007843993 @default.
- W1646234539 cites W2013533451 @default.
- W1646234539 cites W2015860573 @default.
- W1646234539 cites W2037608002 @default.
- W1646234539 cites W2046920160 @default.
- W1646234539 cites W2050044629 @default.
- W1646234539 cites W2053330484 @default.
- W1646234539 cites W2063406324 @default.
- W1646234539 cites W2075883530 @default.
- W1646234539 cites W2090594360 @default.
- W1646234539 cites W2402953327 @default.
- W1646234539 cites W72086436 @default.
- W1646234539 cites W9479973 @default.
- W1646234539 doi "https://doi.org/10.1016/s0021-9258(18)32845-x" @default.
- W1646234539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6826555" @default.
- W1646234539 hasPublicationYear "1983" @default.
- W1646234539 type Work @default.
- W1646234539 sameAs 1646234539 @default.
- W1646234539 citedByCount "88" @default.
- W1646234539 countsByYear W16462345392012 @default.
- W1646234539 countsByYear W16462345392016 @default.
- W1646234539 crossrefType "journal-article" @default.
- W1646234539 hasAuthorship W1646234539A5032706436 @default.
- W1646234539 hasBestOaLocation W16462345391 @default.
- W1646234539 hasConcept C107824862 @default.
- W1646234539 hasConcept C121608353 @default.
- W1646234539 hasConcept C185592680 @default.
- W1646234539 hasConcept C2776067312 @default.
- W1646234539 hasConcept C51639874 @default.
- W1646234539 hasConcept C530470458 @default.
- W1646234539 hasConcept C54355233 @default.
- W1646234539 hasConcept C55493867 @default.
- W1646234539 hasConcept C84606932 @default.
- W1646234539 hasConcept C86803240 @default.
- W1646234539 hasConcept C95444343 @default.
- W1646234539 hasConceptScore W1646234539C107824862 @default.
- W1646234539 hasConceptScore W1646234539C121608353 @default.
- W1646234539 hasConceptScore W1646234539C185592680 @default.
- W1646234539 hasConceptScore W1646234539C2776067312 @default.
- W1646234539 hasConceptScore W1646234539C51639874 @default.
- W1646234539 hasConceptScore W1646234539C530470458 @default.
- W1646234539 hasConceptScore W1646234539C54355233 @default.
- W1646234539 hasConceptScore W1646234539C55493867 @default.
- W1646234539 hasConceptScore W1646234539C84606932 @default.
- W1646234539 hasConceptScore W1646234539C86803240 @default.
- W1646234539 hasConceptScore W1646234539C95444343 @default.
- W1646234539 hasIssue "5" @default.
- W1646234539 hasLocation W16462345391 @default.
- W1646234539 hasOpenAccess W1646234539 @default.
- W1646234539 hasPrimaryLocation W16462345391 @default.
- W1646234539 hasRelatedWork W1974337437 @default.
- W1646234539 hasRelatedWork W1978168514 @default.
- W1646234539 hasRelatedWork W1986509130 @default.
- W1646234539 hasRelatedWork W1988891933 @default.
- W1646234539 hasRelatedWork W2014906318 @default.
- W1646234539 hasRelatedWork W2051819270 @default.
- W1646234539 hasRelatedWork W2057203476 @default.
- W1646234539 hasRelatedWork W2090428300 @default.
- W1646234539 hasRelatedWork W2102053055 @default.
- W1646234539 hasRelatedWork W2170568819 @default.
- W1646234539 hasVolume "258" @default.
- W1646234539 isParatext "false" @default.
- W1646234539 isRetracted "false" @default.
- W1646234539 magId "1646234539" @default.
- W1646234539 workType "article" @default.