FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W164631372> ?p ?o ?g. }

• W164631372 endingPage "30" @default.
• W164631372 startingPage "624" @default.
• W164631372 abstract "The pattern of chromosomal aberrations and their significance in prostate cancer are poorly understood. We studied 23 prostate cancer and 10 benign prostatic hyperplasia (BPH) specimens by fluorescence in situ hybridization (FISH) using pericentromeric repeat-specific probes for 10 different chromosomes. The aims of the study were: 1) to compare the sensitivity of FISH and DNA flow cytometry in aneuploidy detection, 2) to determine which chromosome copy number changes are most common, and 3) which probe combinations would be most effective in aneuploidy diagnosis. Disaggregated tumor cells from formalin-fixed, paraffin-embedded tissues were pretreated with our newly developed method based on hot glycerol solution to improve probe penetration. All BPH specimens were diploid by DNA flow cytometry and showed no numerical chromosome aberrations by FISH. In prostate cancer, flow cytometry showed abnormal DNA content in 35% of cases, whereas 74% were abnormal by FISH. Aberrant copy number of chromosomes 8 (48% of cases), X (43% of cases), and 7 (39% of cases) were most common. Ninety-four percent of all aneuploid cases would have been detected with these three probes alone. Simple chromosome losses were uncommon but in DNA tetraploid tumors relative losses (trisomy or disomy) of several chromosomes were often found, suggesting progression of prostate cancer through tetraploidization followed by losses of selected chromosomes. In conclusion, our results indicate that FISH using three selected chromosome-specific probes is two to three times more sensitive than flow cytometric DNA content analysis in aneuploidy detection." @default.
• W164631372 created "2016-06-24" @default.
• W164631372 creator A5017338157 @default.
• W164631372 creator A5028823431 @default.
• W164631372 creator A5065324555 @default.
• W164631372 creator A5068108014 @default.
• W164631372 creator A5084933963 @default.
• W164631372 date "1994-09-01" @default.
• W164631372 modified "2023-09-23" @default.
• W164631372 title "Sensitive detection of chromosome copy number aberrations in prostate cancer by fluorescence in situ hybridization." @default.
• W164631372 cites W1488193995 @default.
• W164631372 cites W1600954336 @default.
• W164631372 cites W1848781389 @default.
• W164631372 cites W1972153062 @default.
• W164631372 cites W1973319827 @default.
• W164631372 cites W1977752124 @default.
• W164631372 cites W2002931312 @default.
• W164631372 cites W2014928680 @default.
• W164631372 cites W2018542689 @default.
• W164631372 cites W2022368084 @default.
• W164631372 cites W2028823791 @default.
• W164631372 cites W2029858185 @default.
• W164631372 cites W2031856439 @default.
• W164631372 cites W2040974016 @default.
• W164631372 cites W2042337149 @default.
• W164631372 cites W2054045654 @default.
• W164631372 cites W2059070156 @default.
• W164631372 cites W2068550037 @default.
• W164631372 cites W2069644796 @default.
• W164631372 cites W2081998349 @default.
• W164631372 cites W2102590970 @default.
• W164631372 cites W2108318591 @default.
• W164631372 cites W2113674897 @default.
• W164631372 cites W2121341625 @default.
• W164631372 cites W2124156899 @default.
• W164631372 cites W2131287825 @default.
• W164631372 cites W2395224249 @default.
• W164631372 cites W2403955614 @default.
• W164631372 cites W2426274300 @default.
• W164631372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1890337" @default.
• W164631372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8080044" @default.
• W164631372 hasPublicationYear "1994" @default.
• W164631372 type Work @default.
• W164631372 sameAs 164631372 @default.
• W164631372 citedByCount "31" @default.
• W164631372 countsByYear W1646313722015 @default.
• W164631372 countsByYear W1646313722017 @default.
• W164631372 crossrefType "journal-article" @default.
• W164631372 hasAuthorship W164631372A5017338157 @default.
• W164631372 hasAuthorship W164631372A5028823431 @default.
• W164631372 hasAuthorship W164631372A5065324555 @default.
• W164631372 hasAuthorship W164631372A5068108014 @default.
• W164631372 hasAuthorship W164631372A5084933963 @default.
• W164631372 hasConcept C104317684 @default.
• W164631372 hasConcept C121608353 @default.
• W164631372 hasConcept C124942203 @default.
• W164631372 hasConcept C130197536 @default.
• W164631372 hasConcept C142724271 @default.
• W164631372 hasConcept C143191323 @default.
• W164631372 hasConcept C153911025 @default.
• W164631372 hasConcept C2776229224 @default.
• W164631372 hasConcept C2777542201 @default.
• W164631372 hasConcept C2779672484 @default.
• W164631372 hasConcept C2780192828 @default.
• W164631372 hasConcept C30481170 @default.
• W164631372 hasConcept C54355233 @default.
• W164631372 hasConcept C552990157 @default.
• W164631372 hasConcept C553184892 @default.
• W164631372 hasConcept C71924100 @default.
• W164631372 hasConcept C86803240 @default.
• W164631372 hasConceptScore W164631372C104317684 @default.
• W164631372 hasConceptScore W164631372C121608353 @default.
• W164631372 hasConceptScore W164631372C124942203 @default.
• W164631372 hasConceptScore W164631372C130197536 @default.
• W164631372 hasConceptScore W164631372C142724271 @default.
• W164631372 hasConceptScore W164631372C143191323 @default.
• W164631372 hasConceptScore W164631372C153911025 @default.
• W164631372 hasConceptScore W164631372C2776229224 @default.
• W164631372 hasConceptScore W164631372C2777542201 @default.
• W164631372 hasConceptScore W164631372C2779672484 @default.
• W164631372 hasConceptScore W164631372C2780192828 @default.
• W164631372 hasConceptScore W164631372C30481170 @default.
• W164631372 hasConceptScore W164631372C54355233 @default.
• W164631372 hasConceptScore W164631372C552990157 @default.
• W164631372 hasConceptScore W164631372C553184892 @default.
• W164631372 hasConceptScore W164631372C71924100 @default.
• W164631372 hasConceptScore W164631372C86803240 @default.
• W164631372 hasIssue "3" @default.
• W164631372 hasLocation W1646313721 @default.
• W164631372 hasOpenAccess W164631372 @default.
• W164631372 hasPrimaryLocation W1646313721 @default.
• W164631372 hasRelatedWork W164631372 @default.
• W164631372 hasRelatedWork W1997484496 @default.
• W164631372 hasRelatedWork W2006984821 @default.
• W164631372 hasRelatedWork W2021718194 @default.
• W164631372 hasRelatedWork W2049522647 @default.
• W164631372 hasRelatedWork W2119150179 @default.
• W164631372 hasRelatedWork W2169164598 @default.

• next