Matches in SemOpenAlex for { <https://semopenalex.org/work/W1646367159> ?p ?o ?g. }
- W1646367159 endingPage "143" @default.
- W1646367159 startingPage "138" @default.
- W1646367159 abstract "Toll-like receptors (TLRs) play a fundamental role in the recognition of bacteria and viruses. TLR3 is activated by viral dsRNA and polyinosinic-polycytidylic acid (poly(I:C)), a synthetic mimetic of viral RNA. We show that NK cells, known for their capacity to eliminate virally infected cells, express TLR3 and up-regulate TLR3 mRNA upon poly(I:C) stimulation. Treatment of highly purified NK cells with poly(I:C) significantly augments NK cell-mediated cytotoxicity. Poly(I:C) stimulation also leads to up-regulation of activation marker CD69 on NK cells. Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma. The induction of cytokine production by NK cells was preceded by activation of NF-kappaB. We conclude that the ability of NK cells to directly recognize and respond to viral products is important in mounting effective antiviral responses." @default.
- W1646367159 created "2016-06-24" @default.
- W1646367159 creator A5015280128 @default.
- W1646367159 creator A5027306178 @default.
- W1646367159 creator A5059657257 @default.
- W1646367159 creator A5063862150 @default.
- W1646367159 creator A5069404903 @default.
- W1646367159 creator A5073930077 @default.
- W1646367159 creator A5085541901 @default.
- W1646367159 creator A5088785832 @default.
- W1646367159 date "2004-01-01" @default.
- W1646367159 modified "2023-10-16" @default.
- W1646367159 title "APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA" @default.
- W1646367159 cites W1483162601 @default.
- W1646367159 cites W1514540900 @default.
- W1646367159 cites W1519633296 @default.
- W1646367159 cites W1534496719 @default.
- W1646367159 cites W1778677407 @default.
- W1646367159 cites W1934712179 @default.
- W1646367159 cites W1966280572 @default.
- W1646367159 cites W1970753581 @default.
- W1646367159 cites W1972776583 @default.
- W1646367159 cites W1973157062 @default.
- W1646367159 cites W1978926805 @default.
- W1646367159 cites W1983528955 @default.
- W1646367159 cites W1988672382 @default.
- W1646367159 cites W1991236592 @default.
- W1646367159 cites W1995866508 @default.
- W1646367159 cites W2002469544 @default.
- W1646367159 cites W2006073656 @default.
- W1646367159 cites W2013601771 @default.
- W1646367159 cites W2019292780 @default.
- W1646367159 cites W2033431215 @default.
- W1646367159 cites W2040038008 @default.
- W1646367159 cites W2046915211 @default.
- W1646367159 cites W2047150754 @default.
- W1646367159 cites W2047567850 @default.
- W1646367159 cites W2058860008 @default.
- W1646367159 cites W2071727569 @default.
- W1646367159 cites W2076361525 @default.
- W1646367159 cites W2077808289 @default.
- W1646367159 cites W2089738808 @default.
- W1646367159 cites W2099019634 @default.
- W1646367159 cites W2104904748 @default.
- W1646367159 cites W2110223162 @default.
- W1646367159 cites W2114637517 @default.
- W1646367159 cites W2130649175 @default.
- W1646367159 cites W2133449490 @default.
- W1646367159 cites W2134224958 @default.
- W1646367159 cites W2135358991 @default.
- W1646367159 cites W2148387062 @default.
- W1646367159 cites W2151777859 @default.
- W1646367159 cites W2157861528 @default.
- W1646367159 cites W2159250989 @default.
- W1646367159 cites W2164212445 @default.
- W1646367159 cites W2999065750 @default.
- W1646367159 cites W4313342475 @default.
- W1646367159 cites W4379365691 @default.
- W1646367159 doi "https://doi.org/10.4049/jimmunol.172.1.138" @default.
- W1646367159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14688319" @default.
- W1646367159 hasPublicationYear "2004" @default.
- W1646367159 type Work @default.
- W1646367159 sameAs 1646367159 @default.
- W1646367159 citedByCount "226" @default.
- W1646367159 countsByYear W16463671592012 @default.
- W1646367159 countsByYear W16463671592013 @default.
- W1646367159 countsByYear W16463671592014 @default.
- W1646367159 countsByYear W16463671592015 @default.
- W1646367159 countsByYear W16463671592016 @default.
- W1646367159 countsByYear W16463671592017 @default.
- W1646367159 countsByYear W16463671592018 @default.
- W1646367159 countsByYear W16463671592019 @default.
- W1646367159 countsByYear W16463671592020 @default.
- W1646367159 countsByYear W16463671592021 @default.
- W1646367159 countsByYear W16463671592022 @default.
- W1646367159 countsByYear W16463671592023 @default.
- W1646367159 crossrefType "journal-article" @default.
- W1646367159 hasAuthorship W1646367159A5015280128 @default.
- W1646367159 hasAuthorship W1646367159A5027306178 @default.
- W1646367159 hasAuthorship W1646367159A5059657257 @default.
- W1646367159 hasAuthorship W1646367159A5063862150 @default.
- W1646367159 hasAuthorship W1646367159A5069404903 @default.
- W1646367159 hasAuthorship W1646367159A5073930077 @default.
- W1646367159 hasAuthorship W1646367159A5085541901 @default.
- W1646367159 hasAuthorship W1646367159A5088785832 @default.
- W1646367159 hasBestOaLocation W16463671591 @default.
- W1646367159 hasConcept C129374314 @default.
- W1646367159 hasConcept C136449434 @default.
- W1646367159 hasConcept C149532602 @default.
- W1646367159 hasConcept C154317977 @default.
- W1646367159 hasConcept C164027704 @default.
- W1646367159 hasConcept C169760540 @default.
- W1646367159 hasConcept C170493617 @default.
- W1646367159 hasConcept C185592680 @default.
- W1646367159 hasConcept C202751555 @default.
- W1646367159 hasConcept C203014093 @default.
- W1646367159 hasConcept C24998067 @default.
- W1646367159 hasConcept C2776090121 @default.