Matches in SemOpenAlex for { <https://semopenalex.org/work/W1646400510> ?p ?o ?g. }
- W1646400510 endingPage "5879" @default.
- W1646400510 startingPage "5874" @default.
- W1646400510 abstract "IL-16 has been reported as a modulator of T cell activation and was shown to function as chemoattractant factor. The chemotactic activity of IL-16 depends on the expression of CD4 on the surface of target cells, but the intracellular signaling pathways are only now being deciphered. This report describes IL-16 as an additional activator of the stress-activated protein kinase (SAPK) pathway in CD4+ macrophages. Treatment of these cells with recombinant expressed IL-16 leads to the phosphorylation of SEK-1, resulting in activation of the SAPKs p46 and p54. IL-16 stimulation also leads to the phosphorylation of c-Jun and p38 MAPK (mitogen-activated protein kinase), without inducing MAPK-family members ERK-1 and ERK-2. Interestingly, the IL-16-mediated activation of SAPKs and p38 MAPK in macrophages alone induces no detectable apoptotic cell death. These observations suggest specific regulatory functions of IL-16 distinct from the proinflammatory cytokines TNF-alpha and IL-1beta." @default.
- W1646400510 created "2016-06-24" @default.
- W1646400510 creator A5013041037 @default.
- W1646400510 date "1998-06-15" @default.
- W1646400510 modified "2023-10-18" @default.
- W1646400510 title "IL-16 Activates the SAPK Signaling Pathway in CD4+ Macrophages" @default.
- W1646400510 cites W1414643142 @default.
- W1646400510 cites W1485021502 @default.
- W1646400510 cites W1502915328 @default.
- W1646400510 cites W1505173991 @default.
- W1646400510 cites W1519809500 @default.
- W1646400510 cites W1542412714 @default.
- W1646400510 cites W1573821584 @default.
- W1646400510 cites W1587892340 @default.
- W1646400510 cites W163125452 @default.
- W1646400510 cites W1671728707 @default.
- W1646400510 cites W1873493101 @default.
- W1646400510 cites W1911507086 @default.
- W1646400510 cites W1932535232 @default.
- W1646400510 cites W1955217315 @default.
- W1646400510 cites W1965529603 @default.
- W1646400510 cites W1968590447 @default.
- W1646400510 cites W1971334343 @default.
- W1646400510 cites W1976462601 @default.
- W1646400510 cites W1977302628 @default.
- W1646400510 cites W1982390204 @default.
- W1646400510 cites W1984204941 @default.
- W1646400510 cites W1984665850 @default.
- W1646400510 cites W1984903682 @default.
- W1646400510 cites W1987453246 @default.
- W1646400510 cites W1990056722 @default.
- W1646400510 cites W1994080507 @default.
- W1646400510 cites W1994975139 @default.
- W1646400510 cites W1995819749 @default.
- W1646400510 cites W1998487776 @default.
- W1646400510 cites W1999823156 @default.
- W1646400510 cites W2001399809 @default.
- W1646400510 cites W2002292023 @default.
- W1646400510 cites W2003962192 @default.
- W1646400510 cites W2004319639 @default.
- W1646400510 cites W2004822307 @default.
- W1646400510 cites W2007986629 @default.
- W1646400510 cites W2025458258 @default.
- W1646400510 cites W2025548430 @default.
- W1646400510 cites W2026515182 @default.
- W1646400510 cites W2026951979 @default.
- W1646400510 cites W2031610264 @default.
- W1646400510 cites W2032731042 @default.
- W1646400510 cites W2035693310 @default.
- W1646400510 cites W2036985660 @default.
- W1646400510 cites W2042260090 @default.
- W1646400510 cites W2046216255 @default.
- W1646400510 cites W2055884802 @default.
- W1646400510 cites W2058384478 @default.
- W1646400510 cites W2062412222 @default.
- W1646400510 cites W2071607357 @default.
- W1646400510 cites W2072654899 @default.
- W1646400510 cites W2075012700 @default.
- W1646400510 cites W2077880395 @default.
- W1646400510 cites W2078901242 @default.
- W1646400510 cites W2080719576 @default.
- W1646400510 cites W2082190322 @default.
- W1646400510 cites W2086766576 @default.
- W1646400510 cites W2094872845 @default.
- W1646400510 cites W2099729324 @default.
- W1646400510 cites W2133355304 @default.
- W1646400510 cites W2147678437 @default.
- W1646400510 cites W2186749740 @default.
- W1646400510 cites W2418248245 @default.
- W1646400510 cites W2418334496 @default.
- W1646400510 cites W4245286388 @default.
- W1646400510 cites W4294216491 @default.
- W1646400510 doi "https://doi.org/10.4049/jimmunol.160.12.5874" @default.
- W1646400510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9637499" @default.
- W1646400510 hasPublicationYear "1998" @default.
- W1646400510 type Work @default.
- W1646400510 sameAs 1646400510 @default.
- W1646400510 citedByCount "39" @default.
- W1646400510 countsByYear W16464005102013 @default.
- W1646400510 countsByYear W16464005102014 @default.
- W1646400510 countsByYear W16464005102015 @default.
- W1646400510 countsByYear W16464005102016 @default.
- W1646400510 countsByYear W16464005102017 @default.
- W1646400510 countsByYear W16464005102018 @default.
- W1646400510 countsByYear W16464005102021 @default.
- W1646400510 countsByYear W16464005102023 @default.
- W1646400510 crossrefType "journal-article" @default.
- W1646400510 hasAuthorship W1646400510A5013041037 @default.
- W1646400510 hasBestOaLocation W16464005101 @default.
- W1646400510 hasConcept C11960822 @default.
- W1646400510 hasConcept C164027704 @default.
- W1646400510 hasConcept C170493617 @default.
- W1646400510 hasConcept C184235292 @default.
- W1646400510 hasConcept C185592680 @default.
- W1646400510 hasConcept C203014093 @default.
- W1646400510 hasConcept C2776914184 @default.
- W1646400510 hasConcept C51551487 @default.
- W1646400510 hasConcept C54166955 @default.