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• W1646625758 abstract "Research Article1 July 1985free access Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. G. Selten G. Selten Search for more papers by this author H.T. Cuypers H.T. Cuypers Search for more papers by this author A. Berns A. Berns Search for more papers by this author G. Selten G. Selten Search for more papers by this author H.T. Cuypers H.T. Cuypers Search for more papers by this author A. Berns A. Berns Search for more papers by this author Author Information G. Selten, H.T. Cuypers and A. Berns The EMBO Journal (1985)4:1793-1798https://doi.org/10.1002/j.1460-2075.1985.tb03852.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Proviral integration near the Pim-1 gene is frequently observed in murine leukemia virus induced T-cell lymphomas in mice. Integration in the Pim-1 domain is associated with the presence of enhanced levels of a Pim-1 mRNA, which is normally expressed as a predominant 2.8 kb species at low levels in lymphoid tissues. The majority of integrations occurred in the 3′ region of the Pim-1 transcription unit. This resulted in transcripts ranging in size from 2.0 to 2.6 kb, which were terminated in the 5′ proviral LTR. Dependent on the site of integration up to 1300 bases of Pim-1 specific sequences were missing from the modified Pim-1 mRNA in these lymphomas. Previous ArticleNext Article Volume 4Issue 71 July 1985In this issue RelatedDetailsLoading ..." @default.
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• W1646625758 date "1985-07-01" @default.
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• W1646625758 title "Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas." @default.
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• W1646625758 doi "https://doi.org/10.1002/j.1460-2075.1985.tb03852.x" @default.
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