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• W1646998001 abstract "The Review of Diabetic Studies,2009,6,3,203-210.DOI:10.1900/RDS.2009.6.203Published:November 2009Type:Review Article Authors:Lina Nordquist, and John Wahren Author(s) affiliations:Lina Nordquist1 and John Wahren2 1Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, 75123 Uppsala, Sweden. 2Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Abstract:Proinsulin C-peptide has been found to exert beneficial effects in many tissues affected by diabetic microvascular complications, including the kidneys. Glomerular hyperfiltration and microalbuminuria are early markers of diabetic nephropathy. C-peptide at physiological concentrations effectively reduces diabetes-induced glomerular hyperfiltration via constriction of the afferent arteriole, dilation of the efferent arteriole, and inhibition of tubular reabsorption in experimental models of type 1 diabetes. The glomerular hypertrophy and mesangial matrix expansion seen in early diabetes can be reduced or prevented by C-peptide administration, possibly via interference with TGF-β1 and TNFα signaling. Several of C-peptide’s reno-protective effects have been confirmed in human studies; reduced glomerular hyperfiltration and diminished urinary albumin excretion have been documented in type 1 diabetes patients receiving replacement doses of C-peptide for periods of up to 3 months. In this review, we critically summarize the current state of knowledge regarding C-peptide’s renal effects, and discuss possible mechanisms of its beneficial effects in diabetic nephropathy. Keywords:C-peptide, Capillary pressure, Diabetes, Glomerular hypertrophy, Microalbuminuria, NephropathyView:RevDiabeticStud-6-3-203.pdf (2.93 MB)" @default.
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• W1646998001 date "2009-01-01" @default.
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• W1646998001 title "C-Peptide: The Missing Link in Diabetic Nephropathy?" @default.
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• W1646998001 doi "https://doi.org/10.1900/rds.2009.6.203" @default.
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