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- W1647201977 abstract "The diterpene ester promoter of mouse skin tumors, 12-O-tetradecanoyl-phorbol-13-acetate, induced a DNase activity in the Epstein-Barr virus-producer cell line P3HR-1. The elution patterns of the enzyme from DEAE-cellulose, phosphocellulose, and DNA-cellulose columns were different from virus-associated DNA polymerase activity. The partially purified activity could be neutralized to the extent of 90% by sera of patients with nasopharyngeal carcinoma. Purified immunoglobulin G from sera of nasopharyngeal carcinoma patients inhibited this enzyme and that obtained from superinfected Raji cells to the same extent. The partially purified enzyme preferred native DNA as a substrate over denatured DNA and 3'-terminally labeled activated calf thymus DNA. The activity was inhibited by high ionic strength. Phosphonoformic acid did not have any effect on this enzyme activity." @default.
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- W1647201977 date "1982-12-01" @default.
- W1647201977 modified "2023-09-26" @default.
- W1647201977 title "Identification and characterization of a DNase induced by Epstein-Barr virus" @default.
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- W1647201977 doi "https://doi.org/10.1128/jvi.44.3.893-899.1982" @default.
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