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- W1648442908 abstract "Clinical islet transplantation has proved beneficial for many patients with diabetes, but in its current form, it is reserved only for those patients with the most severe disease. When patients are evaluated for islet transplantation, their metabolic status and diabetes-related secondary complications should be carefully characterized so that those patients who would receive the greatest benefit despite the requirement for lifelong immunosuppression are selected. Current selection criteria for islet-alone transplantation include a hypoglycemia (HYPO) score > 1047 (90th percentile), lability index (LI) > 433 mmol/L 2 /h.week -1 (90th percentile), or a composite with the HYPO score > 423 (75th percentile) and LI > 329 (75th percentile). Since patients with poor diabetes compliance or an inadequate baseline insulin regimen are likely to benefit from improved design of their insulin dosing regimens, patients selected for transplant should have plasma hemoglobin levels (HbA1C) < 10%. There are two potentially serious procedural complications in islet transplantation: bleeding from the catheter tract created by the percutaneous transhepatic approach and portal vein thrombosis, particularly when large volumes of tissue are infused. The islet isolation process subjects islets to significant ischemic and physical injury, rendering them susceptible to post-transplantation stresses. As an endocrine tissue, islets require a means to sample representative glucose levels and be able to deliver insulin through a relevant route to its target tissues. Ideally, a transplanted islet should reside in a site with minimal immunological attack and low levels of post-transplantation β-cell apoptosis, such as that induced by the IBMIR." @default.
- W1648442908 created "2016-06-24" @default.
- W1648442908 creator A5032815945 @default.
- W1648442908 creator A5041560044 @default.
- W1648442908 creator A5087340333 @default.
- W1648442908 date "2011-01-01" @default.
- W1648442908 modified "2023-09-25" @default.
- W1648442908 title "Clinical Islet Transplantation" @default.
- W1648442908 cites W1485526722 @default.
- W1648442908 cites W1511608972 @default.
- W1648442908 cites W1520719913 @default.
- W1648442908 cites W1540138335 @default.
- W1648442908 cites W1548625552 @default.
- W1648442908 cites W1581554632 @default.
- W1648442908 cites W1623137528 @default.
- W1648442908 cites W1667957779 @default.
- W1648442908 cites W1696581921 @default.
- W1648442908 cites W1752045965 @default.
- W1648442908 cites W1966045277 @default.
- W1648442908 cites W1975785257 @default.
- W1648442908 cites W1976370313 @default.
- W1648442908 cites W1979302709 @default.
- W1648442908 cites W1980557101 @default.
- W1648442908 cites W1984762682 @default.
- W1648442908 cites W1985673750 @default.
- W1648442908 cites W1987694689 @default.
- W1648442908 cites W1988299309 @default.
- W1648442908 cites W1992555742 @default.
- W1648442908 cites W1995505731 @default.
- W1648442908 cites W2003945383 @default.
- W1648442908 cites W2005677214 @default.
- W1648442908 cites W2006497957 @default.
- W1648442908 cites W2006786209 @default.
- W1648442908 cites W2008477650 @default.
- W1648442908 cites W2012549523 @default.
- W1648442908 cites W2013862339 @default.
- W1648442908 cites W2016124159 @default.
- W1648442908 cites W2017478720 @default.
- W1648442908 cites W2020915357 @default.
- W1648442908 cites W2021400383 @default.
- W1648442908 cites W2022121727 @default.
- W1648442908 cites W2022126895 @default.
- W1648442908 cites W2023492750 @default.
- W1648442908 cites W2023728676 @default.
- W1648442908 cites W2024711583 @default.
- W1648442908 cites W2026322690 @default.
- W1648442908 cites W2027737067 @default.
- W1648442908 cites W2031484324 @default.
- W1648442908 cites W2034627511 @default.
- W1648442908 cites W2034633281 @default.
- W1648442908 cites W2035055926 @default.
- W1648442908 cites W2036387511 @default.
- W1648442908 cites W2037190164 @default.
- W1648442908 cites W2041496770 @default.
- W1648442908 cites W2045416646 @default.
- W1648442908 cites W2046703988 @default.
- W1648442908 cites W2050110586 @default.
- W1648442908 cites W2052721366 @default.
- W1648442908 cites W2053386318 @default.
- W1648442908 cites W2054361177 @default.
- W1648442908 cites W2057976504 @default.
- W1648442908 cites W2058160440 @default.
- W1648442908 cites W2058657286 @default.
- W1648442908 cites W2058857909 @default.
- W1648442908 cites W2064241921 @default.
- W1648442908 cites W2065788737 @default.
- W1648442908 cites W2066117828 @default.
- W1648442908 cites W2066808970 @default.
- W1648442908 cites W2067305414 @default.
- W1648442908 cites W2070380688 @default.
- W1648442908 cites W2073282913 @default.
- W1648442908 cites W2073391786 @default.
- W1648442908 cites W2074332806 @default.
- W1648442908 cites W2075863039 @default.
- W1648442908 cites W2076033444 @default.
- W1648442908 cites W2076770967 @default.
- W1648442908 cites W2077612514 @default.
- W1648442908 cites W2078657091 @default.
- W1648442908 cites W2082090910 @default.
- W1648442908 cites W2083700216 @default.
- W1648442908 cites W2086317674 @default.
- W1648442908 cites W2087954194 @default.
- W1648442908 cites W2092702917 @default.
- W1648442908 cites W2097517798 @default.
- W1648442908 cites W2098338322 @default.
- W1648442908 cites W2099761979 @default.
- W1648442908 cites W2100493615 @default.
- W1648442908 cites W2100714478 @default.
- W1648442908 cites W2102172815 @default.
- W1648442908 cites W2102915416 @default.
- W1648442908 cites W2104269891 @default.
- W1648442908 cites W2106219965 @default.
- W1648442908 cites W2106261209 @default.
- W1648442908 cites W2107346812 @default.
- W1648442908 cites W2108040825 @default.
- W1648442908 cites W2108979344 @default.
- W1648442908 cites W2109832090 @default.
- W1648442908 cites W2112036459 @default.