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• W1648485202 abstract "7 INTRODUCTION 9 REVIEW OF THE LITERATURE 10 1. SARCOMAS 10 1.1. Soft tissue sarcomas 10 1.2. Bone sarcomas 11 2. GENETIC CHARACTERISTICS OF SARCOMAS 12 3. GENERAL FEATURES OF SARCOMAS STUDIED IN THIS THESIS 16 3.1. Dermatofibrosarcoma protuberans (DFSP) 16 3.2. Soft tissue leiomyosarcoma (LMS) 16 3.3. Uterine leiomyosarcoma (ULMS) 17 3.4. Malignant fibrous histiocytoma (MFH) 19 3.5. Osteosarcoma (OS) 19 4. MOLECULAR GENETIC ANALYSIS OF SARCOMA 21 4.1. Copy number changes by comparative genomic hybridization 21 4.2. Application of comparative genomic hybridization in sarcoma genetics 23 4.3. Quantitative analysis of genetic alterations 27 5. IMPACT OF DNA COPY NUMBER CHANGES 27 5.1. Oncogene activation by DNA copy number amplifications 27 5.2. Tumour suppressor gene inactivation by DNA copy number loss 29 5.3. Pathway analysis based on aCGH data 31 AIMS OF THE STUDY 34 MATERIALS AND METHODS 35 1. Sarcoma specimens and DNA extraction (I-V) 35 2. Chromosomal comparative genomic hybridization (I-V) 36 3. Array comparative genomic hybridization (1-V) 38 4. Data analysis (I-V) 38 5. Statistical analysis (V) 39 6. Ethical permissions (I-V) 39" @default.
• W1648485202 created "2016-06-24" @default.
• W1648485202 creator A5081360033 @default.
• W1648485202 date "2007-06-15" @default.
• W1648485202 modified "2023-09-27" @default.
• W1648485202 title "ARRAY COMPARATIVE GENOMIC HYBRIDIZATION IN SARCOMAS" @default.
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