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• W1649202239 abstract "Thermosensitive polymer-coated La0.73Sr0.27MnO3 (LSMO) nanoparticles with a core-shell structure were prepared as a heat-generating agent for magnetic hyperthermia therapy and magnetically activated drug delivery systems. The magnetic cores of LSMO nanoparticles with an average particle size of 54 nm were prepared using the citrate gel method. Then, the surface of the nanoparticles was successfully coated with poly(N-isopropylacrylamide-co-acrylamide) (PNIPAAm-co-AAm) through admicellar polymerization method. First, the surfaces of the nanoparticles were coated with a bilayer surfactant containing oleic acid and SDS as an inner and outer layer surfactant, respectively. Then, the polymerization was carried out at 70 °C to enforce the adsolubilization of monomers in the hydrophobic interlayer between the two self-organized surfactants that coated each particle. The heat generation efficiency of the PNIPAAm-co-AAm-coated LSMO nanoparticles under various alternating magnetic fields was determined by induction heating analysis. The results showed that the maximum temperature attained by the nanoparticles falls within the desired therapeutic temperature range, which is suitable for cancer hyperthermia therapy and magnetically activated drug delivery systems. poly(N-isopropylacrylamide-co-acrylamide) copolymer-coated La0.73Sr0.27MnO3 nanoparticles were prepared through admicellar polymerization. The prepared nanoparticles with core-shell can be used as heat-generating agent in magnetic hyperthermia therapy." @default.
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• W1649202239 date "2015-09-09" @default.
• W1649202239 modified "2023-10-17" @default.
• W1649202239 title "Thermosensitive polymer-coated La0.73Sr0.27MnO3 nanoparticles: potential applications in cancer hyperthermia therapy and magnetically activated drug delivery systems" @default.
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• W1649202239 doi "https://doi.org/10.1038/pj.2015.66" @default.
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