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- W1649203797 abstract "β-Carotene (BC) has assumed importance as an anticarcinogen, both in epidemiologic studies in human beings and in animal models. Recent publications show that the fibroblastic cell line C3H/10T1/2, BC, and canthaxanthin inhibit chemically and physically induced transformation without being converted to retinol, retinal, or retinoic acid (RA). Another important property of BC that has been known for a long time is its lack of toxicity in contrast to retinol. When increasing concentrations of BC are given to rats, the conversion of BC to retinol levels off before the retinol produced becomes toxic. In a study of liver storage of vitamin A in rats and chicks fed with BC, it is reported that for the rat in the range of about one to a maximum of 10 times the daily vitamin A requirement, BC is completely absorbed and transformed to vitamin A, with a relationship of one molecule BC corresponding to one molecule of retinol. With a higher intake, the log of the absorption or transformation rate decreases linearly, inverse to the log of intake." @default.
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- W1649203797 date "1993-01-01" @default.
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- W1649203797 title "[3] Uptake and cleavage of β-carotene by cultures of rat small intestinal cells and human lung fibroblasts" @default.
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- W1649203797 doi "https://doi.org/10.1016/0076-6879(93)14050-s" @default.
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