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- W1650325260 abstract "Abstract Caspase (Casp) family proteases regulate not only lymphocyte apoptosis but also lymphocyte activation and development. In this study, we show that Casp6 regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G1 than wild-type B cells, and mitogen-induced G1 entry of Casp6 KO B cells is much faster than that of wild-type B cells. Even so, S phase entry and proliferation are not increased in Casp6 KO B cells. Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1+ plasma cells and produce Abs. In Casp6 KO mice compared with WT mice, serum levels of IgG1, IgG2a, and IgG2b are increased and Ag-specific Ab responses are also enhanced along with increased percentages of syndecan-1+ plasma cells. Casp6 may regulate both B cell activation and differentiation by modifying requirements for G0 B cells to enter G1." @default.
- W1650325260 created "2016-06-24" @default.
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- W1650325260 date "2008-11-15" @default.
- W1650325260 modified "2023-10-11" @default.
- W1650325260 title "Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells" @default.
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- W1650325260 doi "https://doi.org/10.4049/jimmunol.181.10.6810" @default.
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