FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1650530076> ?p ?o ?g. }

• W1650530076 endingPage "11732" @default.
• W1650530076 startingPage "11719" @default.
• W1650530076 abstract "Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR including umbelliferone (1), osthol (2), scopoletin (3), peucedanol (4), ulopterol (5), angepubebisin (6), psoralen (7), xanthotoxin (8), bergapten (9), isoimperatorin (10), columbianadin (11), and columbianetin acetate (12) with an in vitro model using a MDCK-pHaMDR cell monolayer. The cell monolayer was validated to be suitable for the permeation experiments. The samples’ transports were analyzed by high performance liquid chromatography and their apparent permeability coefficients (Papp) were calculated. According to the Papp value, most coumarins could be characterized as well-absorbed compounds except for 4, 10 and 11 which were moderately absorbed ones, in concentration-dependent and time-dependent manners. The results of P-glycoprotein (P-gp) inhibitor (verapamil) experiments showed that the transport of coumarin 4 was affected by the transport protein P-gp. Sigmoid functions between permeability log(Papp AP-BL*MW0.5) and log D (at pH 7.4) were established to analyze the structure-activity relationship of coumarins. The results provide useful information for discovering the substance basis for the central nervous system activities of APR, and predicting the permeability of other coumarins through BBB." @default.
• W1650530076 created "2016-06-24" @default.
• W1650530076 creator A5009247381 @default.
• W1650530076 creator A5061537073 @default.
• W1650530076 creator A5062312562 @default.
• W1650530076 creator A5069820275 @default.
• W1650530076 date "2015-06-25" @default.
• W1650530076 modified "2023-10-18" @default.
• W1650530076 title "Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability" @default.
• W1650530076 cites W1937048566 @default.
• W1650530076 cites W1973091091 @default.
• W1650530076 cites W1973856630 @default.
• W1650530076 cites W1977675317 @default.
• W1650530076 cites W1987464387 @default.
• W1650530076 cites W1996027158 @default.
• W1650530076 cites W1998584026 @default.
• W1650530076 cites W1999884107 @default.
• W1650530076 cites W2003263277 @default.
• W1650530076 cites W2007859813 @default.
• W1650530076 cites W2008269302 @default.
• W1650530076 cites W2012244264 @default.
• W1650530076 cites W2015348924 @default.
• W1650530076 cites W2019702066 @default.
• W1650530076 cites W2021466124 @default.
• W1650530076 cites W2039748871 @default.
• W1650530076 cites W2071644397 @default.
• W1650530076 cites W2077178129 @default.
• W1650530076 cites W2077216169 @default.
• W1650530076 cites W2083698650 @default.
• W1650530076 cites W2104574190 @default.
• W1650530076 cites W2114356223 @default.
• W1650530076 cites W2125133167 @default.
• W1650530076 cites W2136660346 @default.
• W1650530076 cites W2159821105 @default.
• W1650530076 cites W2400949896 @default.
• W1650530076 doi "https://doi.org/10.3390/molecules200711719" @default.
• W1650530076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332004" @default.
• W1650530076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26121397" @default.
• W1650530076 hasPublicationYear "2015" @default.
• W1650530076 type Work @default.
• W1650530076 sameAs 1650530076 @default.
• W1650530076 citedByCount "35" @default.
• W1650530076 countsByYear W16505300762015 @default.
• W1650530076 countsByYear W16505300762016 @default.
• W1650530076 countsByYear W16505300762017 @default.
• W1650530076 countsByYear W16505300762018 @default.
• W1650530076 countsByYear W16505300762019 @default.
• W1650530076 countsByYear W16505300762020 @default.
• W1650530076 countsByYear W16505300762021 @default.
• W1650530076 countsByYear W16505300762022 @default.
• W1650530076 countsByYear W16505300762023 @default.
• W1650530076 crossrefType "journal-article" @default.
• W1650530076 hasAuthorship W1650530076A5009247381 @default.
• W1650530076 hasAuthorship W1650530076A5061537073 @default.
• W1650530076 hasAuthorship W1650530076A5062312562 @default.
• W1650530076 hasAuthorship W1650530076A5069820275 @default.
• W1650530076 hasBestOaLocation W16505300761 @default.
• W1650530076 hasConcept C120882062 @default.
• W1650530076 hasConcept C142724271 @default.
• W1650530076 hasConcept C169760540 @default.
• W1650530076 hasConcept C178790620 @default.
• W1650530076 hasConcept C185592680 @default.
• W1650530076 hasConcept C202751555 @default.
• W1650530076 hasConcept C204787440 @default.
• W1650530076 hasConcept C2777307396 @default.
• W1650530076 hasConcept C2778402981 @default.
• W1650530076 hasConcept C2779020807 @default.
• W1650530076 hasConcept C2779091547 @default.
• W1650530076 hasConcept C2780473948 @default.
• W1650530076 hasConcept C2781110370 @default.
• W1650530076 hasConcept C2781338262 @default.
• W1650530076 hasConcept C41625074 @default.
• W1650530076 hasConcept C43617362 @default.
• W1650530076 hasConcept C529278444 @default.
• W1650530076 hasConcept C552990157 @default.
• W1650530076 hasConcept C55493867 @default.
• W1650530076 hasConcept C59822182 @default.
• W1650530076 hasConcept C71924100 @default.
• W1650530076 hasConcept C86803240 @default.
• W1650530076 hasConceptScore W1650530076C120882062 @default.
• W1650530076 hasConceptScore W1650530076C142724271 @default.
• W1650530076 hasConceptScore W1650530076C169760540 @default.
• W1650530076 hasConceptScore W1650530076C178790620 @default.
• W1650530076 hasConceptScore W1650530076C185592680 @default.
• W1650530076 hasConceptScore W1650530076C202751555 @default.
• W1650530076 hasConceptScore W1650530076C204787440 @default.
• W1650530076 hasConceptScore W1650530076C2777307396 @default.
• W1650530076 hasConceptScore W1650530076C2778402981 @default.
• W1650530076 hasConceptScore W1650530076C2779020807 @default.
• W1650530076 hasConceptScore W1650530076C2779091547 @default.
• W1650530076 hasConceptScore W1650530076C2780473948 @default.
• W1650530076 hasConceptScore W1650530076C2781110370 @default.
• W1650530076 hasConceptScore W1650530076C2781338262 @default.
• W1650530076 hasConceptScore W1650530076C41625074 @default.
• W1650530076 hasConceptScore W1650530076C43617362 @default.
• W1650530076 hasConceptScore W1650530076C529278444 @default.
• W1650530076 hasConceptScore W1650530076C552990157 @default.
• W1650530076 hasConceptScore W1650530076C55493867 @default.

• next