FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1650765478> ?p ?o ?g. }

• W1650765478 endingPage "577" @default.
• W1650765478 startingPage "572" @default.
• W1650765478 abstract "Background Loss of heterozygosity (LOH) on chromosome arm 3p, where the gene of thyroid hormone receptor beta (THRB) is located, has been reported in breast cancer. Although some studies performed in vitro have suggested that THRB could act as a tumor suppressor in breast cancer development, there is still no unequivocal evidence to support this. Methods To determine the role of LOH in breast tumor development, the LOH of THRB and its proximal microsatellite markers D3S1293, D3S3659, D3S3700, D3S2307 and D3S2336 was investigated in a genomic region spanning ~3.3 Mb in tumor specimens and in corresponding normal tissues of 74 invasive breast cancer patients. The association was analyzed between LOH in microsatellite markers and clinicopathological characteristics. Results LOH was detected in D3S1293 (36.7%), THRB (59.4%), D3S3659 (37.5%) and D3S3700 (55.2%) among the informative cases, while LOH was not detected in D3S2307 and D3S2336. Cases exhibited LOH of 52.8%-71.4% if any 2 markers were combined and analyzed out of the first 4 microsatellite markers. LOH in THRB was associated with negative estrogen receptor (ER), negative progesterone receptor (PR), both negative estrogen receptor and progesterone receptor (HR) and human epidermal growth factor receptor-2 (HER2) and lymph node metastasis (p = 0.0001, p = 0.005, p = 0.001 and p = 0.018). The association with negative PR in LOH in THRB and/or D3S1293 was pronounced (p<0.0001). LOH in D3S3700 showed an association with lymph node metastasis (p = 0.014). This association was enhanced if D3S3700 was combined with THRB or D3S3659 (p = 0.0004, p = 0.0002). Conclusions LOH in THRB and its proximal microsatellite markers may play a role in tumorigenesis and development in invasive breast cancer." @default.
• W1650765478 created "2016-06-24" @default.
• W1650765478 creator A5011811036 @default.
• W1650765478 creator A5017035787 @default.
• W1650765478 creator A5032886760 @default.
• W1650765478 creator A5065420532 @default.
• W1650765478 creator A5066102428 @default.
• W1650765478 creator A5080704061 @default.
• W1650765478 creator A5086213047 @default.
• W1650765478 date "2015-03-08" @default.
• W1650765478 modified "2023-10-05" @default.
• W1650765478 title "Loss of Heterozygosity in Thyroid Hormone Receptor Beta in Invasive Breast Cancer" @default.
• W1650765478 cites W1985405072 @default.
• W1650765478 cites W2002307433 @default.
• W1650765478 cites W2007133293 @default.
• W1650765478 cites W2007865928 @default.
• W1650765478 cites W2012979834 @default.
• W1650765478 cites W2018227401 @default.
• W1650765478 cites W2021041647 @default.
• W1650765478 cites W2031946108 @default.
• W1650765478 cites W2035162346 @default.
• W1650765478 cites W2036069015 @default.
• W1650765478 cites W2041988832 @default.
• W1650765478 cites W2042343487 @default.
• W1650765478 cites W2049475256 @default.
• W1650765478 cites W2065129915 @default.
• W1650765478 cites W2068359064 @default.
• W1650765478 cites W2073365753 @default.
• W1650765478 cites W2076709640 @default.
• W1650765478 cites W2082660634 @default.
• W1650765478 cites W2127146920 @default.
• W1650765478 cites W2142343504 @default.
• W1650765478 cites W2321228152 @default.
• W1650765478 cites W4214487521 @default.
• W1650765478 doi "https://doi.org/10.5301/tj.5000272" @default.
• W1650765478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26350179" @default.
• W1650765478 hasPublicationYear "2015" @default.
• W1650765478 type Work @default.
• W1650765478 sameAs 1650765478 @default.
• W1650765478 citedByCount "6" @default.
• W1650765478 countsByYear W16507654782017 @default.
• W1650765478 countsByYear W16507654782018 @default.
• W1650765478 countsByYear W16507654782019 @default.
• W1650765478 countsByYear W16507654782021 @default.
• W1650765478 countsByYear W16507654782022 @default.
• W1650765478 countsByYear W16507654782023 @default.
• W1650765478 crossrefType "journal-article" @default.
• W1650765478 hasAuthorship W1650765478A5011811036 @default.
• W1650765478 hasAuthorship W1650765478A5017035787 @default.
• W1650765478 hasAuthorship W1650765478A5032886760 @default.
• W1650765478 hasAuthorship W1650765478A5065420532 @default.
• W1650765478 hasAuthorship W1650765478A5066102428 @default.
• W1650765478 hasAuthorship W1650765478A5080704061 @default.
• W1650765478 hasAuthorship W1650765478A5086213047 @default.
• W1650765478 hasConcept C104317684 @default.
• W1650765478 hasConcept C109115496 @default.
• W1650765478 hasConcept C121608353 @default.
• W1650765478 hasConcept C126322002 @default.
• W1650765478 hasConcept C134018914 @default.
• W1650765478 hasConcept C143589142 @default.
• W1650765478 hasConcept C149574134 @default.
• W1650765478 hasConcept C180754005 @default.
• W1650765478 hasConcept C23589133 @default.
• W1650765478 hasConcept C502942594 @default.
• W1650765478 hasConcept C526584372 @default.
• W1650765478 hasConcept C530470458 @default.
• W1650765478 hasConcept C54355233 @default.
• W1650765478 hasConcept C71924100 @default.
• W1650765478 hasConcept C84606932 @default.
• W1650765478 hasConcept C86803240 @default.
• W1650765478 hasConcept C98717036 @default.
• W1650765478 hasConceptScore W1650765478C104317684 @default.
• W1650765478 hasConceptScore W1650765478C109115496 @default.
• W1650765478 hasConceptScore W1650765478C121608353 @default.
• W1650765478 hasConceptScore W1650765478C126322002 @default.
• W1650765478 hasConceptScore W1650765478C134018914 @default.
• W1650765478 hasConceptScore W1650765478C143589142 @default.
• W1650765478 hasConceptScore W1650765478C149574134 @default.
• W1650765478 hasConceptScore W1650765478C180754005 @default.
• W1650765478 hasConceptScore W1650765478C23589133 @default.
• W1650765478 hasConceptScore W1650765478C502942594 @default.
• W1650765478 hasConceptScore W1650765478C526584372 @default.
• W1650765478 hasConceptScore W1650765478C530470458 @default.
• W1650765478 hasConceptScore W1650765478C54355233 @default.
• W1650765478 hasConceptScore W1650765478C71924100 @default.
• W1650765478 hasConceptScore W1650765478C84606932 @default.
• W1650765478 hasConceptScore W1650765478C86803240 @default.
• W1650765478 hasConceptScore W1650765478C98717036 @default.
• W1650765478 hasIssue "5" @default.
• W1650765478 hasLocation W16507654781 @default.
• W1650765478 hasLocation W16507654782 @default.
• W1650765478 hasOpenAccess W1650765478 @default.
• W1650765478 hasPrimaryLocation W16507654781 @default.
• W1650765478 hasRelatedWork W1498598852 @default.
• W1650765478 hasRelatedWork W2014364223 @default.
• W1650765478 hasRelatedWork W2058784350 @default.
• W1650765478 hasRelatedWork W2093476509 @default.
• W1650765478 hasRelatedWork W2096799980 @default.

• next