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- W165079377 abstract "The neural networks that putatively modulate the evaluative, expressive, and experiential aspects of emotional behavior have been implicated in the pathophysiology of mood disorders by converging evidence from neuroimaging, neuropathological, and lesion analysis studies. These networks involve the orbital and medial prefrontal cortex (OMPFC), amygdala, hippocampus, and anatomically related areas of the basal ganglia where alterations in gray matter volume and neurophysiological activity exist in some subgroups with mood disorders. These findings hold implications for neurocircuitry models of depression, since they suggest that impaired OMPFC function can dysregulate or disinhibit function in limbic projections that organize emotional expression in experimental animals, and thereby induce depressive syndromes in humans. This chapter discusses a neural model positing that the combined effects of impaired OMPFC function and disinhibited limbic activity may account for the disturbances of emotional behavior, cognitive performance, neurotransmission, autonomic regulation, and neuroendocrine responses associated with mood disorders." @default.
- W165079377 created "2016-06-24" @default.
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- W165079377 date "2009-01-01" @default.
- W165079377 modified "2023-09-27" @default.
- W165079377 title "Depression and the Brain" @default.
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- W165079377 doi "https://doi.org/10.1016/b978-008045046-9.00846-9" @default.
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