FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W165096684> ?p ?o ?g. }

• W165096684 endingPage "37" @default.
• W165096684 startingPage "1" @default.
• W165096684 abstract "Capsaicin, the pungent ingredient of red pepper has become not only a hot topic in neuroscience but its new target-related unique actions have opened the door for the drug industry to introduce a new chapter of analgesics. After several lines of translational efforts with over 1,000 patents and clinical trials, the 8% capsaicin dermal patch reached the market and its long-lasting local analgesic effect in some severe neuropathic pain states is now well established. This introductory chapter outlines on one hand the historical background based on the author's 50 years of experience in this field and on the other hand emphasizes new scopes, fascinating perspectives in pharmaco-physiology, and molecular pharmacology of nociceptive sensory neurons. Evidence for the effect of capsaicin on C-polymodal nociceptors (CMH), C-mechanoinsensitive (CHMi), and silent C-nociceptors are listed and the features of the capsaicin-induced blocking effects of nociceptors are demonstrated. Common and different characteristics of nociceptor-blocking actions after systemic, perineural, local, intrathecal, and in vitro treatments are summarized. Evidence for the misleading conclusions drawn from neonatal capsaicin pretreatment is presented. Perspectives opened from cloning the capsaicin receptor Transient Receptor Potential Vanilloid 1 (TRPV1) are outlined and potential molecular mechanisms behind the long-lasting functional, ultrastructural, and nerve terminal-damaging effects of capsaicin and other TRPV1 agonists are summarized. Neurogenic inflammation and the long-list of capsaicin-sensitive tissue responses are mediated by an unorthodox dual sensory-efferent function of peptidergic TRPV1-expressing nerve terminals which differ from the classical efferent and sensory nerve endings that have a unidirectional role in neuroregulation. Thermoregulatory effects of capsaicin are discussed in detail. It is suggested that since hyperthermia and burn risk due to enhanced noxious heat threshold are the major obstacles of some TRPV1 antagonists, they could be overcome. The special multisteric gating function of the TRPV1 cation channel provides the structural ground for blocking chemical activation of TRPV1 without affecting its responsiveness to physical stimuli. A new chapter of potential analgesics targeting nociceptors is now already supported for pain relief in persistent pathological pain states." @default.
• W165096684 created "2016-06-24" @default.
• W165096684 creator A5079050175 @default.
• W165096684 date "2014-01-01" @default.
• W165096684 modified "2023-10-01" @default.
• W165096684 title "Capsaicin and Sensory Neurones: A Historical Perspective" @default.
• W165096684 cites W102683574 @default.
• W165096684 cites W103292242 @default.
• W165096684 cites W10864851 @default.
• W165096684 cites W116208630 @default.
• W165096684 cites W1248435168 @default.
• W165096684 cites W1482716043 @default.
• W165096684 cites W1497394880 @default.
• W165096684 cites W1511198581 @default.
• W165096684 cites W1593680573 @default.
• W165096684 cites W1628129021 @default.
• W165096684 cites W1769392980 @default.
• W165096684 cites W1808582964 @default.
• W165096684 cites W1883060277 @default.
• W165096684 cites W1935733657 @default.
• W165096684 cites W1963883696 @default.
• W165096684 cites W1964123630 @default.
• W165096684 cites W1965797600 @default.
• W165096684 cites W1966916866 @default.
• W165096684 cites W1967506194 @default.
• W165096684 cites W1969655931 @default.
• W165096684 cites W1969906137 @default.
• W165096684 cites W1970677487 @default.
• W165096684 cites W1970745458 @default.
• W165096684 cites W1971086034 @default.
• W165096684 cites W1972541147 @default.
• W165096684 cites W1972803792 @default.
• W165096684 cites W1973806783 @default.
• W165096684 cites W1974691601 @default.
• W165096684 cites W1974705948 @default.
• W165096684 cites W1975293054 @default.
• W165096684 cites W1975348529 @default.
• W165096684 cites W1976221887 @default.
• W165096684 cites W1979224927 @default.
• W165096684 cites W1979953535 @default.
• W165096684 cites W1983877535 @default.
• W165096684 cites W1985464800 @default.
• W165096684 cites W1986042301 @default.
• W165096684 cites W1987192367 @default.
• W165096684 cites W1988916164 @default.
• W165096684 cites W1989103258 @default.
• W165096684 cites W1990427801 @default.
• W165096684 cites W1990822834 @default.
• W165096684 cites W1993886374 @default.
• W165096684 cites W1993958507 @default.
• W165096684 cites W1994223329 @default.
• W165096684 cites W1994366534 @default.
• W165096684 cites W1998242194 @default.
• W165096684 cites W1998697854 @default.
• W165096684 cites W2001155177 @default.
• W165096684 cites W2001778425 @default.
• W165096684 cites W2001990910 @default.
• W165096684 cites W2005103650 @default.
• W165096684 cites W2005415930 @default.
• W165096684 cites W2005505879 @default.
• W165096684 cites W2007560318 @default.
• W165096684 cites W2008045899 @default.
• W165096684 cites W2009838891 @default.
• W165096684 cites W2010641024 @default.
• W165096684 cites W2010841889 @default.
• W165096684 cites W2010852772 @default.
• W165096684 cites W2011904838 @default.
• W165096684 cites W2014779151 @default.
• W165096684 cites W2014869536 @default.
• W165096684 cites W2015697709 @default.
• W165096684 cites W2019234091 @default.
• W165096684 cites W2020158187 @default.
• W165096684 cites W2022937463 @default.
• W165096684 cites W2024903090 @default.
• W165096684 cites W2025347721 @default.
• W165096684 cites W2025745642 @default.
• W165096684 cites W2026462774 @default.
• W165096684 cites W2029360579 @default.
• W165096684 cites W2030681860 @default.
• W165096684 cites W2033223894 @default.
• W165096684 cites W2035429056 @default.
• W165096684 cites W2035930718 @default.
• W165096684 cites W2036038321 @default.
• W165096684 cites W2037364614 @default.
• W165096684 cites W2038848442 @default.
• W165096684 cites W2039393505 @default.
• W165096684 cites W2039605663 @default.
• W165096684 cites W2042966883 @default.
• W165096684 cites W2044783562 @default.
• W165096684 cites W2047609544 @default.
• W165096684 cites W2049952694 @default.
• W165096684 cites W2050579065 @default.
• W165096684 cites W2051576958 @default.
• W165096684 cites W2052066577 @default.
• W165096684 cites W2053864414 @default.
• W165096684 cites W2054442714 @default.
• W165096684 cites W2054830932 @default.
• W165096684 cites W2055335617 @default.

• next