Matches in SemOpenAlex for { <https://semopenalex.org/work/W165123764> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W165123764 abstract "Stimulation of endothelin B (ETB) receptors can increase neuronal oxidative stress, and consequently sympathetic nerve activity. Therefore we tested the hypothesis that the pressor response to ET-1 is partially mediated by the ETB receptor-mediated release of constrictor neurotransmitters from perivascular nerves. Pressor responses to the selective ETB receptor agonist sarafotoxin (S6c) were examined in anesthetized female, wild-type (WT) and ETB receptor-deficient (sl/sl) rats during ganglion blockade. S6c produced dose-dependent increases in arterial pressure in both WT and sl/sl rats. In WT rats, pretreatment with the selective α1 adrenergic antagonist prazosin (1 mg/kg) had no effect on the pressor response. Conversely, in sl/sl rats, S6c caused a maintained depressor response to 0.3 and 1.0 nmol/kg S6c (steady state: −7±3 and −11±3 mmHg @ 0.3 and 1.0 nmol/kg, respectively) in the presence of prazosin. Pressor responses were restored, however, by the combination of α1 and β adrenergic (propranolol; 5 mg/kg) blockade (peak: 12±2, 11±1, and 16±4 mmHg @ 0.1, 0.3, and 1.0 nmol/kg, respectively). Because functional ETB receptors are expressed only in neuronal tissue in sl/sl rats, these data suggest that responses to S6c are achieved by the ETB receptor-dependent release of neurotransmitters from perivascular nerves, including a yet unidentified non-adrenergic vasoconstrictor neurotransmitter(s)." @default.
- W165123764 created "2016-06-24" @default.
- W165123764 creator A5020571019 @default.
- W165123764 creator A5077014832 @default.
- W165123764 creator A5084264952 @default.
- W165123764 date "2007-01-01" @default.
- W165123764 modified "2023-09-27" @default.
- W165123764 title "Dependence of the endothelin‐mediated pressor response on neuronal ET B ‐mediated neurotransmitter release in sl/sl rats" @default.
- W165123764 doi "https://doi.org/10.1096/fasebj.21.6.a886-b" @default.
- W165123764 hasPublicationYear "2007" @default.
- W165123764 type Work @default.
- W165123764 sameAs 165123764 @default.
- W165123764 citedByCount "0" @default.
- W165123764 crossrefType "journal-article" @default.
- W165123764 hasAuthorship W165123764A5020571019 @default.
- W165123764 hasAuthorship W165123764A5077014832 @default.
- W165123764 hasAuthorship W165123764A5084264952 @default.
- W165123764 hasConcept C126322002 @default.
- W165123764 hasConcept C134018914 @default.
- W165123764 hasConcept C144980905 @default.
- W165123764 hasConcept C170493617 @default.
- W165123764 hasConcept C185592680 @default.
- W165123764 hasConcept C24998067 @default.
- W165123764 hasConcept C2776219046 @default.
- W165123764 hasConcept C2776885963 @default.
- W165123764 hasConcept C2778122271 @default.
- W165123764 hasConcept C2778196918 @default.
- W165123764 hasConcept C2778938600 @default.
- W165123764 hasConcept C2780648677 @default.
- W165123764 hasConcept C2909649922 @default.
- W165123764 hasConcept C2911175447 @default.
- W165123764 hasConcept C71924100 @default.
- W165123764 hasConceptScore W165123764C126322002 @default.
- W165123764 hasConceptScore W165123764C134018914 @default.
- W165123764 hasConceptScore W165123764C144980905 @default.
- W165123764 hasConceptScore W165123764C170493617 @default.
- W165123764 hasConceptScore W165123764C185592680 @default.
- W165123764 hasConceptScore W165123764C24998067 @default.
- W165123764 hasConceptScore W165123764C2776219046 @default.
- W165123764 hasConceptScore W165123764C2776885963 @default.
- W165123764 hasConceptScore W165123764C2778122271 @default.
- W165123764 hasConceptScore W165123764C2778196918 @default.
- W165123764 hasConceptScore W165123764C2778938600 @default.
- W165123764 hasConceptScore W165123764C2780648677 @default.
- W165123764 hasConceptScore W165123764C2909649922 @default.
- W165123764 hasConceptScore W165123764C2911175447 @default.
- W165123764 hasConceptScore W165123764C71924100 @default.
- W165123764 hasIssue "6" @default.
- W165123764 hasLocation W1651237641 @default.
- W165123764 hasOpenAccess W165123764 @default.
- W165123764 hasPrimaryLocation W1651237641 @default.
- W165123764 hasRelatedWork W1983371938 @default.
- W165123764 hasRelatedWork W2026413470 @default.
- W165123764 hasRelatedWork W2042710245 @default.
- W165123764 hasRelatedWork W2068436091 @default.
- W165123764 hasRelatedWork W2253476305 @default.
- W165123764 hasRelatedWork W2340893788 @default.
- W165123764 hasRelatedWork W2393521223 @default.
- W165123764 hasRelatedWork W4238880647 @default.
- W165123764 hasRelatedWork W4247776882 @default.
- W165123764 hasRelatedWork W1953368919 @default.
- W165123764 hasVolume "21" @default.
- W165123764 isParatext "false" @default.
- W165123764 isRetracted "false" @default.
- W165123764 magId "165123764" @default.
- W165123764 workType "article" @default.