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- W1651992610 abstract "The chapter that addresses the Ig germ line gene organization in lupus-prone strains of mice suggested that the disease can develop in different Ig heavy and light chain haplotypes, and that the Ig germ line genes in lupus mice are probably normal. Analyses of the Ig gene segments expressed in monoclonal autoantibodies from autoimmune mice revealed that similar, moreover, in some instances even identical, gene segments are expressed in autoantibodies and in antibodies to exogenous antigens, and that antiself and antiforeign responses are encoded by the same, or at least an overlapping, germ line gene repertoire. Evidence has been obtained that, in an individual lupus mouse, the number of autoantibody-secreting clonotypes decreases after class switch, while that of productive mutations increases, suggesting that antiself responses might be (auto) antigen-driven responses, but this conclusion should be considered tentative. Finally, based on the investigations of I-E and Mls tolerance-related Vβ clonal deletions, the chapter proposes that the abnormally proliferating, autoimmunity-inducing/enhancing double-negative TcR α:β+ lpr and gld cells are not related to immature CD4-8- thymocytes, but instead are derived from CD4 + 8 + precursors through a process resulting in down-regulation of both accessory molecules." @default.
- W1651992610 created "2016-06-24" @default.
- W1651992610 creator A5004663851 @default.
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- W1651992610 creator A5041108174 @default.
- W1651992610 creator A5085640372 @default.
- W1651992610 date "1989-01-01" @default.
- W1651992610 modified "2023-10-13" @default.
- W1651992610 title "Molecular Genetics of Murine Lupus Models" @default.
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