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• W165204032 abstract "Research Article1 July 1992free access Regulation of CFTR expression and function during differentiation of intestinal epithelial cells. R. Sood R. Sood Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author C. Bear C. Bear Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author W. Auerbach W. Auerbach Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author E. Reyes E. Reyes Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author T. Jensen T. Jensen Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author N. Kartner N. Kartner Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author J.R. Riordan J.R. Riordan Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author M. Buchwald M. Buchwald Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author R. Sood R. Sood Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author C. Bear C. Bear Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author W. Auerbach W. Auerbach Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author E. Reyes E. Reyes Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author T. Jensen T. Jensen Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author N. Kartner N. Kartner Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author J.R. Riordan J.R. Riordan Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author M. Buchwald M. Buchwald Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Search for more papers by this author Author Information R. Sood1, C. Bear1, W. Auerbach1, E. Reyes1, T. Jensen1, N. Kartner1, J.R. Riordan1 and M. Buchwald1 1Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. The EMBO Journal (1992)11:2487-2494https://doi.org/10.1002/j.1460-2075.1992.tb05313.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info CFTR, the protein defective in cystic fibrosis is regulated during differentiation of intestinal epithelial cells. The undifferentiated cells (Caco-2 and HT-29) show a lower level of CFTR mRNA, while a 10-fold increase is seen in differentiated cells. These differences correlate well with those of other intestinal-specific genes, including sucrase-isomaltase, villin and alpha 1-antitrypsin, indicating that the regulation is cell specific. In Caco-2 cells the increase in CFTR mRNA cannot be accounted for by increased transcription of the gene. These data indicate that CFTR mRNA stabilizing factor(s) might be present in differentiated cells. The higher levels of CFTR mRNA in differentiated cells are accompanied by decreased protein levels, indicating, as well, involvement of translational control in the regulation of CFTR in these cells. Finally, fully differentiated cells show lowered levels of cyclic AMP-activated C1- transport, the characteristic function of CFTR. Thus, CFTR function in differentiated cells is modulated by a complex interaction of regulatory elements. Caco-2 and HT-29 cells provide a suitable in vitro system in which to study the mechanism of regulation of CFTR. Previous ArticleNext Article Volume 11Issue 71 July 1992In this issue RelatedDetailsLoading ..." @default.
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• W165204032 date "1992-07-01" @default.
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• W165204032 title "Regulation of CFTR expression and function during differentiation of intestinal epithelial cells." @default.
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